Confirmed Brugada Syndrome by either Spontaneous or drug induced Type 1 ECG, confirmed cardiac arrest or appropriate ICD therapy for potentially lethal arrhythmia.

Relatives of Brugada syndrome patients with proven no pathology by Ajmaline challenge

Patients undergoing ablation with ECGi system for other arrhythmias -these patients will be similar to our original controls and provide a repeat set of controls.

Patients with AF undergoing ablation with ECGi system (n=10). These patients will be older and have varying RR intervals which may cause a falsely low V-CoS.

Out-of-hospital cardiac arrest primary PCI with full recovery of left ventricular function and full revascularisation (n=10) - the purpose of this group is to confirm that the changes detected in our SCD group are not secondary to the SCD event. These are patients who have had a cardiac arrest secondary to coronary occlusion, but have made a full recovery with normal LGE-MRI and no indication for ICD.

Athletic Hypertrophy (n=10) - Elite athletes often have physiological LVH and abnormal ECGs at rest. It is unclear if these variations in activation will lead to a decrease in V-CoS.

Brugada Syndrome

Cardiac Arrest

Athletes Heart

Atrial Fibrillation

Ventricular Ectopic Beat

No intervention

Hammersmith Hospital

Feasibility of Improving Risk Stratification in Brugada Syndrome

Method to identify and quantify changes in whole heart activation patterns during physiological stress, V-CoS score between exercise and rest. Test assigns a V-CoS score of '100' when conduction patterns at peak exercise is the same as at rest.

antiadrenergic/fever

Feasibility of Improving Risk Stratification in Brugada Syndrome

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