antiadrenergic/hipersenzitivnost

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Autoantibodies to beta 2-adrenergic receptors with antiadrenergic activity from patients with allergic asthma.

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The serum gamma-globulin fraction from patients with allergic bronchial asthma (8/8), in contrast to the fraction from nonatopic control subjects (10/10), was found to inhibit the positive chronotropic action of the beta 2-selective adrenergic agonist, clenbuterol, on pyruvate- or lactate-treated

Terfenadine, a nonsedating antihistamine.

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Terfenadine is an antihistamine recently approved for use in the U.S. Terfenadine possesses a unique chemical structure when compared with other antihistamines. It is a selective inhibitor of H1-receptors with little or no anticholinergic, antiserotoninergic, or antiadrenergic effects. Comparative

Identification of the cold receptor TRPM8 in the nasal mucosa.

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BACKGROUND The transient receptor potential channel melastatin 8 (TRPM8) has been proposed to be a cold receptor. However, its distribution and physiologic role in the nose is not yet fully explored. OBJECTIVE We investigated the expression of TRPM8 in human nasal mucosa and its function when using

Terfenadine, the first non-sedating antihistamine.

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Alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)- piperidinebutanol (terfenadine, RMI 9918, Triludan, Teldane, resp.) is a potent antagonist of histamine H1-receptor-mediated responses both in vitro and in vivo; no anticholinergic, antiserotonergic or antiadrenergic effects can be

Mizolastine: antihistaminic activity from preclinical data to clinical evaluation.

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Mizolastine, a new H1-receptor antagonist, is highly selective for histamine H1 receptors and has no anticholinergic, antiadrenergic, or antiserotonin activity. It is rapidly absorbed after oral ingestion, with peak plasma concentrations occurring at 1.5 h. The distribution and terminal elimination

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