antiparkinson/glavobolja

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Drug related problems with Antiparkinsonian agents: consumer Internet reports versus published data.

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OBJECTIVE There is currently a lack of detailed information concerning drug related problems in the outpatient treatment of Parkinson's disease. METHODS Problems associated with drug treatment communicated anonymously in Parkinson's disease online forums were therefore retrospectively searched and

Pramipexole in patients with Parkinson's disease and marked drug resistant tremor: a randomised, double blind, placebo controlled multicentre study.

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OBJECTIVE To compare the tremorlytic properties of pramipexole, a non-ergoline dopamine agonist to those of placebo as add on medication in patients with Parkinson's disease. METHODS Eighty four patients with early or advanced Parkinson's disease and marked, drug resistant tremor under a stable and

Levodopa and monoamine oxidase inhibitor combination therapy. A controlled clinical trial.

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During a long-term double-blind study, which began February 1985, we have treated 16 patients with Morbus Parkinson or Parkinson's syndrome with deprenyl or identically appearing placebo tablets. The aim of the study is to ascertain whether a reduction of other antiparkinsonian medication,

Adrogolide HCl (ABT-431; DAS-431), a prodrug of the dopamine D1 receptor agonist, A-86929: preclinical pharmacology and clinical data.

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Adrogolide (ABT-431; DAS-431) is a chemically stable prodrug that is converted rapidly (<1 min) in plasma to A-86929, a full agonist at dopamine D1 receptors. In in vitro functional assays, A-86929 is over 400 times more selective for dopamine D1 than D2 receptors. In rats with a unilateral loss of

Spotlight on rotigotine transdermal patch in Parkinson's disease.

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Rotigotine transdermal patch (Neupro(®)) [referred to here as rotigotine] is a non-ergolinic dopamine agonist that is available in the EU as monotherapy for the treatment of early Parkinson's disease and as combination therapy with levodopa throughout the course of the disease. Daily application of

Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease.

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This study examined the efficacy and safety of the partial dopamine agonist, pardoprunox (SLV308), in the treatment of patients with early Parkinson's disease (PD). Patients were randomized to receive pardoprunox (n = 69) or placebo (n = 70). Pardoprunox was titrated to each patient's optimal dose

[A descriptive epidemiological study of a neurological outpatient clinic].

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OBJECTIVE To evaluate the clinical, diagnostic, therapeutic and functional aspects of a Neurology Outpatient Clinic. METHODS An epidemiological survey was made of 552 neurology patients first seen in the Neurology Outpatient Clinic during a three month period. RESULTS There was a predominance of

Phase-IV multicentre clinical study of risperidone in the treatment of outpatients with schizophrenia. The RIS-CAN-3 Study Group.

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OBJECTIVE Since most clinical trials of atypical antipsychotics have been conducted in hospitalized patients, a Phase-IV, multicentre, 8-week, open-label, flexible-dose study was performed to assess the efficacy and safety of risperidone in outpatients with schizophrenia. METHODS Three hundred and

A case of brucellosis displaying Parkinsonian-like tremor.

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We report a rare case of brucellosis with Parkinsonian-like tremor and simple partial motor seizure. This patient worked as a sheep butcher and the sheep were imported from brucellosis-endemic areas. He presented with classical manifestations of brucellosis; infection was confirmed using the Rose

Lateral ventricular size and drug-induced Parkinsonism.

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Computed Tomography (CT) was used to assess lateral ventricular size in 20 psychiatric inpatients who had participated in at least 5 weeks of a fixed dose chlorpromazine (CPZ) trial. During treatment with CPZ, eight patients had required antiparkinsonian medication for treatment of rigidity. The

Randomized, controlled trial of rasagiline as an add-on to dopamine agonists in Parkinson's disease.

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Dopamine agonists (DA) are often used as first-line monotherapy for the symptomatic control of Parkinson's disease (PD). However, DA monotherapy typically becomes inadequate within a few years, at which time the DA dosage must be increased or other antiparkinsonian medications added. Adding a

Oral hygiene products, medications and drugs - hidden aetiological factors for dental erosion.

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Acidic or EDTA-containing oral hygiene products and acidic medicines have the potential to soften dental hard tissues. The low pH of oral care products increases the chemical stability of some fluoride compounds and favours the incorporation of fluoride ions in the lattice of hydroxyapatite and the

Rotigotine transdermal patch: a review of its use in the treatment of Parkinson's disease.

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A transdermal patch formulation of the non-ergolinic dopamine agonist rotigotine (Neupro®) is indicated as monotherapy for the treatment of early Parkinson's disease and as combination therapy with levodopa throughout the course of the disease. Daily application of the rotigotine transdermal patch

Acute reversible parkinsonism in Epstein-Barr virus-related encephalitis lethargica-like illness.

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A 10-year-old boy presented with fever, headache, vomiting, and hypersomnolence. An akinetic-rigid syndrome with tremor, dysphagia, dysphonia, and sialorrhea, as well as pyramidal signs, developed. Slightly elevated protein content was found in the cerebrospinal fluid and serological investigations

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