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The vascular and cardioprotective effects of liriodenine in ischemia-reperfusion injury via NO-dependent pathway.
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Liriodenine is an aporphine derivative isolated from the plant Fissistigma glaucescens. Electrophysiological action, particularly the blockage of Na+ and K+ channels, contributes to the drug's well-known anti-arrhythmic action. However, liriodenine's cardioprotective efficacy and the relation of the
TM-1-1DP exerts protective effect against myocardial ischemia reperfusion injury via AKT-eNOS pathway.
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Coronary heart disease remains a leading cause of death in the world. The demand on targeting therapy to reduce myocardial ischemia/reperfusion (I/R) injury is still urgent. The pathogenesis of I/R-induced myocardial injury is complicated. Reactive oxygen species (ROS) generation and inflammatory
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