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Vasogenic cerebral edema was induced in rabbits by cold injury. Benzopyrone treatment, started 15 min after freezing, significantly reduced both brain edema and the increased permeability of the blood-brain barrier. On the other hand benzopyrone-treatment was without any effect in cytotoxic brain
On this study, parenchymal changes during a cerebral edema caused by thermic injury (cool) on the rabbit, are analyzed. The work was based on the ultrastructural findings obtained by transmission electronic microscopy and on the effects produced by a benzopironic derived (F-117 Hydrosmina). The
The effect of benzopyrones on edema formation in acute thrombophlebitis was investigated in dogs. Thrombophlebitis was produced by the ligation of the femoral vein and the injection of turpentine oil. The benzopyrones delayed edema formation and sped its regression. Protein concentration in lymph
The lymphedema is a high interstitial protein concentration edema, caused by impaired lymphatic transport capacity. It can be primary or secondary. The secondary form may be caused by a lesion of the lymphatic vessels and/or lymph nodes during diagnostic or therapeutic procedures such as surgical
Increased negativity of the interstitial fluid pressure (P(i)) in the skin is a major driving force to create the initial edema in burn injury and, to a smaller degree, in the edemas formed in the initial phase of the chemical irritation induced by xylene and the anaphylactic reaction induced by
A clinical double-blind study of the effectiveness of the benzopyrone product 5.6-benzo-alpha-pyron + 3',4',7-tris-(hydroxy-ethyl)-rutin (coumarin + troxerutin, Venalot) was investigated in 560 patients following medio-lateral episiotomy. The compound was investigated at various dose levels, and its
OBJECTIVE
To create a phlebolymphologic therapy in order: to activate venous system; to activate lymphatic system; to activate macrophagic system; to reduce the proteic lymphatic load.
METHODS
A study was performed on the use of an ideal phlebolymphological association (Tonka Beans, Gingko Biloba,
Benzopyrones are a class of drugs which have been used clinically and experimentally in Europe and Australia to reduce tissue swelling caused by high-protein edema states. These drugs are not available nor have they been investigated in the United States. This pilot experiment was designed to
The dose-response relationship upon intraperitoneal administration of coumarin (C) and 7-hydroxycoumarin (7HC) in rats was evaluated using the carrageenan induced edema of the hind paw. In a preliminary study C was indicated to reduce the 4-h edema at doses of 10 to 60 mg/kg i.p. Doses of 2.5 and 5
Traumaticed tissue or organs show different reactions to oral and parenteral application of watery solutions. Tissue traumaticed or not does incline to edema. 2. In its central position in blood circulation, its capability of water storage and distribution as well in its regulatory function of the
Several phlebotropic drugs, or edema-protecting drugs, are available, the most important of which are found in the gamma-benzopyrone family (flavonoids). gamma-Benzopyrones can be plant extracts, semisynthetic preparations, or synthetic preparations. This family is divided into two different groups:
The contemporary view of the cause of pain in case of histological lesions is discussed, i.e. the mechanisms of the formation of local high-protein oedemas in connexion with disorders of lymphatic drainage. 295 patients of an oral-surgical department were subjected to a systematic therapeutic study
Using previously presented data, from an open multi-centered trial, the Medians and Third Quartiles were calculated for the overall edema reductions the "average" patient received from an "average" therapist using Complex Physical Therapy (CPT) on 628 lymphedematous limbs. These data provide