Chemotherapy Induced Peripheral Neuropathy

Multiple Myeloma

The algorithm (computer query) will identify all patients who received bortezomib-based chemotherapy for the multiple myeloma indication between 2008 and 2016. All the questionnaires used are validated in the scientific literature.

Bortezomib

CHU Clermont-Ferrand

Prevalence, Intensity and Consequences of Bortezomib-induced Neuropathic Disorders.

Evaluation of the Prevalence, Intensity and Consequences of Bortezomib-induced Neuropathic Disorders: Monocentric Observational and Cross-sectional Study.

Quality of Life Questionnaire - Chemotherapy-Induced Peripheral Neuropathy 20 (QLQ-CIPN20 ; EORTC- European Organisation for Research and Treatment of Cancer).
The questionnaire is divided in 3 subscales: sensory, motor and vegetative. Severity scores summed from 0 to 100. A high score will correspond to the worst symptoms.
Sensory score CIPN20 ≤ 6 = grade 0 NCI-CTCAE
Sensory score CIPN20 > 6 and < 30 = grade 1 NCI-CTCAE
Sensory score CIPN20 ≥ 30 and < 80 = grade 2-3 NCI-CTCAE
Sensory score CIPN20 ≥ 80 = grade 4 NCI-CTCAE.

Pain score rated by a Visual Analog Scale (VAS, 0 (no pain) - 10 (worst possible pain)). Pain will be defined for a score of 4/10.

DN4 questionnaire interview (positive score> 3/7), if VAS pain> 4

Hospital Anxiety and Depression Scale (HADS, summed score from 0 to 21). Score ≤ 7 = no symptomatology, score between 8-10 = suspect symptomatology and score ≥ 11 = consistent symptomatology.

EVA and questions exploring possible hearing problems (professional or leisure activity exposing to noise, habit of having people repeat themselves, problems with telephone comprehension, need to increase television volume, difficulty following a conversation in the presence of noise).

Quality of Life Questionnaire - Chemotherapy 30 (QLQ-C30, EORTC-European Organisation for Research and Treatment of Cancer).
The questionnaire is divided in 3 subscales: Global health, functional and symptomatic.
Severity scores summed from 0 to 100. For the global health scale and the functional scale, a high score will correspond to a better quality of life. For the symptomatic scale, a high score will correspond to a lower quality of life.

catharanthus roseus/atrofija

Prevalence, Intensity and Consequences of Bortezomib-induced Neuropathic Disorders.

Neurotoxic Effect of Bortezomib Treatment in Patient With Myeloma Multiple

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