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cicutoxin/cicuta virosa
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Effects of cicutoxin and related polyacetylenes from Cicuta virosa on neuronal action potentials: a comparative study on the mechanism of the convulsive action.
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Cicutoxin, the convulsant principle of water hemlock, Cicuta virosa L., and the related polyacetylenes isocicutoxin, cicudiol, cicutol, falcarindiol, and falcarinol (20-100 micromol/l) were investigated concerning their influence on electrophysiological parameters using the giant cell RPD1 of the
Cicutoxin from Cicuta virosa--a new and potent potassium channel blocker in T lymphocytes.
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The effect of cicutoxin, the poisonous principle of the genus Cicuta, on K+ currents of activated T lymphocytes was investigated using the patch clamp technique. Cicutoxin produced a dose-dependent [5 x 10(-6) to 7 x 10(-5) mol/l] and completely reversible block of K+ currents with an EC50 of 1.8 x
Polyacetylenes from water hemlock, Cicuta virosa.
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Isolation of polyacetylenes from aerial and subterranean parts of water hemlock, Cicuta virosa L. (Apiaceae. Apioideae), yielded eleven C (17)-polyacetylenes: cicutoxin, cicutol, (8 E,10 E)-heptadecadiene-4,6-diyne-1,12-diol (cicudiol, 7), 2,3-dihydrooenanthetol and (8
Exploring the structural basis of neurotoxicity in C(17)-polyacetylenes isolated from water hemlock.
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Water hemlock, Cicuta virosa, belonging to the Umbelliferae, is well-known as a toxic plant responsible for lethal poisonings in humans as well as animals, causing tonic and clonic convulsions and respiratory paralysis. Cicutoxin (1), being a major violent toxin of the plant, is a chemical in the
New aspects in the treatment of water hemlock poisoning.
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A man inadvertently ate a whole root of the highly poisonous water hemlock (Cicuta virosa L.) plant. The chief symptoms were convulsions, unconsciousness, reddish tinted cyanosis, dilated pupils and marked metabolic acidosis. The patient survived due to treatment with haemodialysis, haemoperfusion,
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