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Codeine and morphine blood concentrations increase during blood loss.

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During extensive blood loss, a plasma volume refill will take place by transfer of extravascular fluid into the circulation. Drugs present in this fluid may follow and cause a rise or a drop in blood drug concentration, depending on their levels and accessibility in the restoration fluid. This study

Methadone, codeine and acute haemorrhagic necrotising pancreatitis: which came first?

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Acute haemorrhagic necrotising pancreatitis lead to the death at home of a young female who was on a methadone maintenance programme. Toxic levels of codeine with potentially lethal levels of methadone and morphine were found at post-mortem. Whether opiates caused the pancreatitis or were the

Prophylactic oral ibuprofen or ibuprofen-codeine versus placebo for postoperative pain after primary hip arthroplasty.

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The postoperative analgesic effect of ibuprofen was compared with a combination of ibuprofen and codeine versus placebo. The study was prospective, randomized, double blind with 123 consecutive hip arthroplasty operations. All the patients received oral diazepam as premedication and spinal

Preoperative ketorolac increases bleeding after tonsillectomy in children.

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OBJECTIVE To compare the incidence of vomiting following codeine or ketorolac for tonsillectomy in children. METHODS We had planned to enrol 240 patients, aged 2-12 yr undergoing elective tonsillectomy into a randomized, single-blind study in University Children's Hospital. The study was terminated,

Magnesium and headache after aneurysmal subarachnoid haemorrhage.

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BACKGROUND In patients with aneurysmal subarachnoid haemorrhage (SAH), headache typically is severe and often requires treatment with opioids. Magnesium has analgesic effects in several conditions, but whether it reduces headache after SAH is unknown. METHODS In a cohort of 108 SAH patients included

Complications related to chronic supratherapeutic use of codeine containing compound analgesics in a cohort of patients presenting for codeine withdrawal.

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This study aimed to compare complications arising due to the supratherapeutic use of paracetamol/codeine or ibuprofen/codeine containing compound analgesics in primary codeine-dependent patients presenting to a drug and alcohol withdrawal service. Data was compared to determine if there was any

Codeine is associated with poor prognosis in acute stroke.

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UNASSIGNED The aim of this study was to investigate how the use of analgesics, sleeping drugs, and sedatives relates to prognosis and complications in stroke patients in the acute care phase (≤48 hr) after a stroke. UNASSIGNED Patients with ischemic stroke, hemorrhagic stroke, and transient ischemic

Postmortem Brain-Blood Ratios of Codeine, Fentanyl, Oxycodone and Tramadol.

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The analgesics, codeine, fentanyl, oxycodone and tramadol frequently occur in postmortem cases and determining their role in the cause of death can be challenging. However, postmortem blood is susceptible to redistribution and may not be available in cases of severe blood loss, putrefaction or

Paracetamol/codeine in relieving pain following removal of impacted mandibular third molars.

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A double-blind clinical study of analgesic drugs was conducted involving 47 healthy adults requiring removal of 90 bony impacted mandibular third molars. The analgesic effect of paracetamol plus codeine (P + C) 350 + 20 mg was compared to that of acetylsalicylic acid (ASA) 500 mg and placebo. A

Effect of naloxone on deficits after aneurysmal subarachnoid hemorrhage.

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The opiate antagonist naloxone was suggested for the amelioration of cerebral ischemia after subarachnoid hemorrhage (SAH) following the 1981 report of clinical improvement of ischemic deficits in 2 patients. The deficit in 1 patient was exacerbated by morphine, suggesting that analgesics acting on

A double-blind evaluation of ketorolac tromethamine versus acetaminophen in pediatric tonsillectomy: analgesia and bleeding.

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The study was designed to compare intravenous ketorolac to rectal acetaminophen for analgesia and bleeding in pediatric patients undergoing tonsillectomy. We studied 50 patients, aged 2-15 yr undergoing tonsillectomy with or without adenoidectomy. In a randomized, prospective double-blind fashion,

Misuse of over-the-counter codeine-containing analgesics: dependence and other adverse effects.

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OBJECTIVE To review cases of codeine dependency from over-the-counter (OTC) combination analgesics admitted to a hospital detoxification unit. METHODS Case records of all admissions following an index case were reviewed over a 2-year period. RESULTS There were 7 cases reporting chronic excess of

Acetaminophen plus codeine compared to ketorolac in polytrauma patients.

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BACKGROUND The management of pain in polytrauma patients is mandatory. While non-steroidal anti-inflammatory drugs (NSAIDs) represent the most used drugs in polytrauma patients, their use may be associated with an increased risk of haemorrhage. Opioids may represent a valid alternative to NSAIDs

Postoperative nonsteroidal anti-inflammatory drugs and risk of bleeding in pediatric intracapsular tonsillectomy.

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OBJECTIVE In light of current FDA guidelines on opioid use in children, we sought to determine the risk of post-tonsillectomy hemorrhage (PTH) in children who received ibuprofen with acetaminophen versus those who received narcotic with acetaminophen for postoperative pain control. METHODS This was

Is tramadol associated to bleeding peptic ulcer? A nationwide case-control study in hospitalized Swedish patients.

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Tramadol, a widely used analgesic drug, inhibits the reuptake of noradrenaline and serotonin impairing the aggregation function of thrombocytes. However, the risk for severe bleeding has previously not been studied. The aim of the present study is to investigate the association between

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