Use of a standard CPAP (continuous positive airway pressure) device with constant pressure for 4 weeks to improve breathing during sleep

Use of CPAP-Flex (continuous positive airway pressure) device with decreased pressure during expiration for 4 weeks to improve breathing during sleep

Participants who were randomized to receive either standard CPAP or CPAP-Flex.

All Study Participants

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

The use (number of hours per night) will be compared between standard CPAP and CPAP flex. Results are based on the first treatment period only (pre-crossover).

Use of a standard CPAP (continuous positive airway pressure) device with constant pressure for 4 weeks to improve breathing during sleep
Standard CPAP: Use of the REMstar Auto A-Flex in standard CPAP therapy mode

Standard CPAP

Use of CPAP-Flex (continuous positive airway pressure) device with decreased pressure during expiration for 4 weeks to improve breathing during sleep
CPAP - Flex: Use of Philips Respironics REMstar Auto A-Flex in C-Flex mode

CPAP-Flex

Adherence to CPAP Pre-crossover

The use (number of hours per night) will be compared between standard CPAP and CPAP flex. Results are based on both periods.

Adherence to CPAP Overall Study

Efficacy will be evaluated by measuring the residual apnea and hypopnea index (AHI) while on treatment. The efficacy of standard CPAP and CPAP-flex will be compared. Results are based on the first treatment period only (pre-crossover).

CPAP - Flex

CPAP Efficacy

Efficacy will be evaluated by measuring the residual apnea and hypopnea index (AHI) while on treatment. The efficacy of standard CPAP and CPAP-flex will be compared. Results are based on both treatment periods.

Participants were first treated with standard CPAP (continuous positive airway pressure with constant pressure) using a REMstar Auto A-flex in standard CPAP therapy mode for 4 weeks. The therapy mode was then switched to CPAP-Flex for 4 weeks. CPAP-Flex provides a decrease in pressure during expiration.

Standard CPAP Followed by CPAP-Flex

Participants were treated with CPAP-Flex (continuous positive airway pressure with a decrease in pressure during expiration) using a REMstar Auto A-flex in C-Flex mode for 4 weeks. The therapy mode was then switched to standard CPAP for 4 weeks. Standard CPAP provides a constant pressure (no decrease after expiration).

CPAP-Flex Followed by Standard CPAP

Period 1 - Initial Assignment

Period 2 -Cross to Alternate Arm

Dr. Jag Sunderram

Obstructive Sleep Apnea

Use of the REMstar Auto A-Flex in standard CPAP therapy mode

Use of Philips Respironics REMstar Auto A-Flex in C-Flex mode

common cold/gojaznost

Obstructive Sleep Apnea in World Trade Center Responders

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