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Type 2 diabetes, but not obesity, prevalence is positively associated with ambient temperature.

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Cold exposure stimulates energy expenditure and glucose disposal. If these factors play a significant role in whole body energy balance, and glucose homeostasis, it is predicted that both obesity and type 2 diabetes prevalence would be lower where it is colder. Previous studies have noted

The thermoregulation of healthy individuals, overweight-obese, and diabetic from the plantar skin thermogram: a clue to predict the diabetic foot.

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Background: Thermoregulation is a complex autonomic process to keep or to dissipate heat in the human body. Methods: In this work, by means of the thermogram of the plantar skin, the thermoregulation of healthy individuals, overweight-obese, and diabetic is discussed. Results: The thermograms of the

Safety and tolerability of a new low-dose contraceptive patch in obese and nonobese women.

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OBJECTIVE The safety and tolerability of a new low-dose levonorgestrel/ethinyl estradiol (LNG/EE) contraceptive patch was compared with 2 combination oral contraceptives in 2 clinical studies in which approximately 30% of enrolled participants were obese. METHODS Two phase 3, open-label, randomized,

Lower critical temperature and cold-induced thermogenesis of lean and overweight humans are inversely related to body mass and basal metabolic rate.

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It is colloquially stated that body size plays a role in the human response to cold, but the magnitude and details of this interaction are unclear. To explore the inherent influence of body size on cold-exposed metabolism, we investigated the relation between body composition and resting metabolic

Pre- and post-weaning cold exposure does not lead to an obese phenotype in adult Brandt's voles (Lasiopodomys brandtii).

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Evidence has shown that postnatal undernutrition, overnutrition and cold stress are associated with imbalanced metabolic regulation as rodents achieve adulthood. In this study, we used a breeding colony of Brandt's voles (Lasiopodomys brandtii), a wild rodent species from the Inner Mongolia

Associations of Serum 25(OH)D Concentrations with Lung Function, Airway Inflammation and Common Cold in the General Population.

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Vitamin D is hypothesized to have a beneficial effect on lung function and respiratory infections. The aim of this study was to assess the relationship of serum 25-hydroxyvitamin D (25(OH)D) concentrations with lung function, airway inflammation and common colds. We performed a cross-sectional

Obesity, dyslipidemia and cholesterol gallstone disease during one year of Antarctic residence.

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BACKGROUND Age, gender, ethnicity, geographic location, diet, obesity, diabetes mellitus and dyslipidemia are known risk factors for development of gallstone disease (GD). We describe the development of four cases of symptomatic GD including a case of acute cholecystitis in Indian Antarctic

Encounters for common illnesses in general practice increased in obese patients.

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BACKGROUND Obese patients are known to have more chronic medical conditions. OBJECTIVE To compare the frequency of encounter for episodes of the 10 most common illnesses in general practice between obese and non-overweight patients. METHODS Data were derived from the Continuous Morbidity

Lorcaserin: a novel serotonin 2C agonist for the treatment of obesity.

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BACKGROUND Obesity has become an epidemic in the United States and its prevalence continues to increase. Adjunctive treatment with pharmacotherapy is often reserved for individuals who fail to achieve their intended weight goals with diet and exercise alone. Current approved therapies for weight

Safety, tolerability, pharmacokinetics, and pharmacodynamics of single-dose antiinterleukin- 18 mAb GSK1070806 in healthy and obese subjects.

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OBJECTIVE To investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of GSK1070806, a novel IgG1 mAb that neutralizes human interleukin (IL)-18. METHODS In this first-timein-human (FTIH) study, cohorts of healthy and obese subjects were randomly allocated to receive single doses

Does global warming contribute to the obesity epidemic?

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Endotherms must expend more energy to digest colder food, so they acquire more calories by eating food at a higher temperature than eating the identical food cold. A recent study shows that ownership of a microwave is associated with a small increase in BMI and obesity. The same logic applies to

Mice lacking the thyroid hormone receptor-alpha gene spend more energy in thermogenesis, burn more fat, and are less sensitive to high-fat diet-induced obesity.

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Unable to activate brown adipose tissue (BAT) thermogenesis, alphaT3-receptor-deficient mice (Thra-0/0) are cold intolerant. Our objective was to investigate the impact on energy economy and mechanisms of the alternate facultative thermogenesis developed. Energy expenditure (oxygen and food

[Multimorbidity patterns in young adults in Catalonia: an analysis of clusters].

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OBJECTIVE The aim of this study was to identify multimorbidity patterns in patients from 19 to 44 years attended in primary care in Catalonia in 2010. METHODS Cross-sectional study. METHODS 251 primary care centres. METHODS 530,798 people with multimorbidity, aged 19 to 44

Is Inflammation a Link Between Self-Reported Health and Infectious Disease Risk?

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Self-reported health (SRH) has been consistently shown to predict morbidity and mortality. However, the mechanisms underlying this association are poorly understood. The study by Cohen and colleagues reported in this issue of Psychosomatic Medicine fills this gap by examining a potential biological

Acute hemolysis of transfused A2 red cells by an auto-HI antibody.

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BACKGROUND Anti-HI is a common cold autoantibody that complicates serologic testing for underlying alloantibodies and has only rarely been associated with hemolysis. An unusual case of an acute hemolytic transfusion reaction (AHTR) due to an anti-HI autoantibody in a subgroup A1 patient transfused

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