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cyclopamine/neuralgia
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Hedgehog signaling regulates nociceptive sensitization.
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BACKGROUND
Nociceptive sensitization is a tissue damage response whereby sensory neurons near damaged tissue enhance their responsiveness to external stimuli. This sensitization manifests as allodynia (aversive withdrawal to previously nonnoxious stimuli) and/or hyperalgesia (exaggerated
Hedgehog Pathway-Mediated Vascular Alterations Following Trigeminal Nerve Injury.
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Whereas neurovascular interactions in spinal neuropathic pain models have been well characterized, little attention has been given to such neurovascular interactions in orofacial neuropathic pain models. This study investigated in male Sprague-Dawley rats the vascular changes following chronic
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