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cystic fibrosis/sambucus

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ČlanciKliničkim ispitivanjimaPatenti
4 rezultati
Destruction of the lungs as a consequence of recurrent infections with microorganisms such as Pseudomonas aeruginosa remains the underlying cause of most morbidity and mortality in cystic fibrosis (CF). We have hypothesized that changes in the glycosylation of key tracheal mucins such as MUC5B and

Glycohistochemical characteristics of nasal polyps from patients with and without cystic fibrosis.

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OBJECTIVE To investigate whether cystic fibrosis (CF)-related nasal polyps exhibit significantly distinct glycohistochemical characteristics when compared with single vs massive nasal polyps obtained from patients without CF. METHODS Glycohistochemical characteristics were identified by means of 8

Terminal sialylation is altered in airway cells with impaired CFTR-mediated chloride transport.

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Reduced terminal sialylation at the surface of airway epithelial cells from patients with cystic fibrosis may predispose them to bacterial infection. To determine whether a lack of chloride transport or misprocessing of mutant cystic fibrosis transmembrane conductance regulator (CFTR) is critical

Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates.

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The cystic fibrosis transmembrane conductance regulator (CFTR) is commonly mutated in cystic fibrosis to the delta F508 CFTR. CFTR has been shown to function as a adenosine 3',5'-cyclic monophosphate-dependent Cl- channel at the cell surface, and there is evidence to suggest that CFTR may also have
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