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dihydroagarofuran/tripterygium
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Dihydroagarofuran derivatives from the dried roots of Tripterygium wilfordii.
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Five new sesquiterpene derivatives, including dihydroagarofuran pyridine macrolides 1-4 and dihydroagarofuran ester 18, and 13 known dihydroagarofuran derivatives were isolated from the aqueous EtOH extract of the dried roots of Tripterygium wilfordii. An in vitro antiherpetic activity assay
Neuroprotective Dihydroagarofuran Sesquiterpene Derivatives from the Leaves of Tripterygium wilfordii.
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Thirteen dihydroagarofuran derivatives, including 12 new sesquiterpenoid esters and one known sesquiterpenoid alkaloid, were obtained from the leaves of Tripterygium wilfordii. Spectroscopic techniques and the ECD method were used for the structure elucidation of the compounds. The structures of
Dihydroagarofuran sesquiterpenoids esterified with organic acids from the leaves of Tripterygium wilfordii.
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Six new and one known dihydroagarofuran sesquiterpenoids esterified with organic acids were obtained from the leaves of Tripterygium wilfordii. Spectroscopic techniques (UV, IR, MS, NMR, ORD and CD) were used for the structure elucidation of the compounds. The structures of compounds 1 and 2 were
Inhibitory effects of dihydroagarofuran sesquiterpenes on Epstein-Barr virus activation.
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To search for possible antitumor promoters, we carried out a primary screening of thirty-seven dihydroagarofuran sesquiterpenes from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, using their possible inhibitory effects on the Epstein-Barr virus early antigen
Anti-inflammatory sesquiterpene pyridine alkaloids from Tripterygium wilfordii.
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During a screening procedure involving higher plants to find novel candidates for use as anti-inflammatory agents, Tripterygium wilfordii Hook. f. was shown to exhibit considerable inhibitory activity. Five new sesquiterpene pyridine alkaloids, tripterygiumines S-W (1-4,15), along with 14 known
A new dihydroagarofuranoid sesquiterpene from the roots of Tripterygium hypoglaucum.
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A new sesquiterpene ester (1) has been isolated from the root bark of Tripterygium hypoglaucum. The structure was determined as 1α-acetoxy-6β,9β-dibenzoyloxy-4β-hydroxy-dihydroagarofuran by the extensive analysis of NMR data, and the absolute configurations were established as 1R, 4R, 6S, and 9R by
Terpene alkaloids from Tripterygium wilfordii.
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Two new sesquiterpene alkaloids, 1beta-hydroxy-2beta,5alpha,11-triacetoxy-7beta-nicotinoyl-8beta-benzoyl-dihydroagarofuran, and 1beta,5alpha,11-triacetoxy-7beta-nicotinoyl-8beta-benzoyl-dihydroagarofuran were isolated from the xylem of Tripterygium wilfordii, together with six known compounds. Their
Sesquiterpene polyol esters from Tripterygium wilfordii.
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The extract (T(II)) of Tripterygium wilfordii Hook f. afforded four sesquiterpene esters: 1beta,2beta,5alpha,8beta,11-pentaacetoxy-4alpha-hydroxy-3alpha(2'-methylbutanoyl)-15-nicotinoyl-7-oxo-dihydroagarofuran;
Immunosuppressive sesquiterpenes from Tripterygium wilfordii.
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Five new sesquiterpenes, 1beta-furanoyl-2beta,3alpha,7alpha,8beta,11-pentaacetoxy-4alpha,5alpha-dihydroxy-dihydroagarofuran (1), 1beta,2beta,3alpha,5alpha,7beta,8beta,11-heptaacetoxy-dihydroagarofuran (2), 1beta-furanoyl-2beta,3alpha,7alpha,8beta,11-pentaacetoxy-5alpha-hydroxy-dihydroagarofuran (3),
Two new sesquiterpenes from the stems of Tripterygium wilfordii
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Two new β-dihydroagarofuran-type sesquiterpenes 1β,2α,6α,8β,15- pentaacetoxy- 9α-benzoyloxy- β-dihydroagarofuran (1) and 1β,2β,6α,15-tetraacetoxy-9β-benzoyloxy- β-dihydroagarofuran (2), together with
Untargeted analysis of sesquiterpene pyridine alkaloids from the dried roots of Tripterygium wilfordii using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.
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BACKGROUND
Sesquiterpene pyridine alkaloids are a large group of highly oxygenated sesquiterpenoids that have attracted attention in the fields of medicine because of their significant biological activities.
METHODS
Reference compounds including 14 sesquiterpene pyridine alkaloids and one
Structure elucidation and NMR assignment of two new hydroxywilfordate-type alkaloids from the stems of Tripterygium hypoglaucum and activity evaluation
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As part of a bioprospecting program aimed at exploration of undiscovered or/and bioactive compounds from the plants located in Yunnan province (China), a phytochemical investigation of a 70% ethanol extract of the stems of Tripterygium hypoglaucum led to the isolation of two previously unreported
Inhibitory effects of triptogelin A-1 on 12-O-tetradecanoylphorbol-13- acetate-induced skin tumor promotion.
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Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Triptogelin A-1,
Dihydro-β-agarofuran sesquiterpenoid derivatives with anti-inflammatory activity from the leaves of Tripterygium wilfordii.
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Triptersinoids A-E (1-5), five undescribed highly oxygenated dihydro-β-agarofuran type sesquiterpenoid polyesters, along with three known analogues were isolated from the aqueous EtOH extracts of the dried leaves of Tripterygium wilfordii. Spectroscopic techniques were used for the elucidation of
Anti-inflammatory sesquiterpene derivatives from the leaves of Tripterygium wilfordii.
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Twelve new dihydroagarofuran sesquiterpene polyol esters, triptersinines A-L (1-12), and eight known sesquiterpene pyridine alkaloids were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of spectroscopic analyses, including UV, IR, and NMR
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