Patients requiring embolization of varicocele, portal vein before ablation, type 2 endoleak, angiomyolipoma or active bleeding will be treated with the liquid embolic agent Easyx during index procedure.

Varicocele

Endoleak

Portal Vein Thrombosis

Bleeding

Angiomyolipoma

Embolization will be done with Easyx liquid agent.

Easyx

AP-HP - Hopital Europeen Georges-Pompidou Paris, France

EASYX-1 : A Multicenter Study on Safety and Efficacy of Easyx Liquid Embolization Agent Used in Five Separate Indications

Expected and unexpected per-procedure (SAE) related to the EASYX™ use (imputability "certain" or "probable")

Percentage of clinical success. The clinical success of type II endoleaks embolization is defined as the stability or reduction of aneurysm's both anterioposterior and transverse diameters assessed on CT-scan at 6 months compared to baseline (4mm threshold).

Percentage of clinical success before ablation for portal vein embolization. The clinical success of portal vein embolization is defined as the growth ≥15 % of the remnant liver assessed on presurgical CT-scan compared to baseline

Percentage of clinical success for varicocele embolization The clinical success of varicocele embolization is defined as the absence of reflux on ultrasound Doppler at one month follow-up.

Percentage of clinical success for angiomyolipoma embolization. The clinical success of angiomyolipoma embolization is defined as the reduction >10% of at least one diameter on MRI or CT-scan at 3 months follow-up compared to baseline

Percentage of clinical success for active bleeding embolization The clinical success of active bleeding embolization is defined as the complete occlusion of the target vessel assessed by angiography during the index procedure

Total number of unanticipated ischemia of the target organ

Total number of secondary post-embolization orchi-epididymitis (varicocele embolization)

Total number of neural root lesion (type II endoleaks)

Total number of aneurysm rupture (type II endoleaks)

Total number of tumor rupture (angiomyolipoma)

Use of Visual Analog Scale (VAS) to evaluate the pain at device injection (between 0: no pain to 10: intolerable pain)

Use of Visual Analog Scale (VAS) to evaluate the painful varicocele (between 0: no pain to 10: intolerable pain)

Total number of unanticipated use of another liquid agent for embolization

Total number of procedures with immediate technical success

Mean volume of EASYX™ used during the index procedure

Mean degree of occlusion of the target vessel(s)

Total number of re-intervention for study procedure

Immediate technical satisfaction questionnaire (as perceived by the Interventional Radiologist)

Total number of embolization clinical efficacy

Total number of procedures with a need to complete with another liquid embolic to achieve optimal result

Technical success at follow-up assessed on CT-scan for type II endoleaks defined as the ability for the physician to give a diagnosis (absence or minor artifacts) on imaging

Assistance Publique - Hôpitaux de Paris

Antia Therapeutics AG

French multicenter, phase 2b (device), prospective study

Cancer affected prepubertal boys will undergo testicular biopsy for testicular fragments cryopreservation. The biopsy will be performed by an attending urologist, before any gonadotoxic therapy is initiated. Testicular biopsy specimens will be divided immediately on the operating table. Two thirds of the specimen will be cryopreserved for potential use by the patient at a later date and will have the patient's details and will stay at the sperm bank of Hadassah Medical Center. The other third of specimen will be used for research purposes in an effort to advance the science of isolating and culturing human SSC's for fertility research.

Oncology [See Also, Affected System]

An open testicular biopsy will be performed by an attending urologist under general anesthesia.

Testicular Biopsy

Hadassah Medical Organization

Fertility Preservation in Prepubertal Boys: An Experimental Approach

The investigators will report the number of cancer affected prepubertal boys that will undergo testicular cryopreservation for future fertility restoration.

In this group all embryos are cryopreserved and two months later embryo transfer will perform.

In this arm fresh embryo transfers are performed on day 2 or 3.

In Vitro Fertilization

freezing embryos by vitrification

fresh embryo transfers

Daily administration of 500 µg subcutaneous buserelin from day 21 of menstrual cycle; reduce to 250 µg daily when ovarian suppression is confirmed.

buserelin

gonadotropin stimulation with rFSH 150 IU/day from day 2 of menstrual cycle

recombinant FSH

hCG 10,000 IU is administered when at least 2 follicles reach a mean diameter of 18 mm.

dimethyl sulfoxide/krvarenje

EASYX-1 : A Multicenter Study on Safety and Efficacy of Easyx Liquid Embolization Agent Used in Five Separate Indications

Fertility Preservation in Prepubertal Boys: An Experimental Approach

Replacement of Fresh Embryo Transfers (ETs) by Frozen Embryo Transfers (FETs) Using Vitrification

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