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Associations of risk factors obesity and occupational airborne exposures with CDKN2A/p16 aberrant DNA methylation in esophageal cancer patients.

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It is known that obesity and occupational airborne exposure such as dust are among risk factors of esophageal cancer development, in particular squamous cell carcinoma (SCC) of esophagus. Here, we tested whether these factors could also affect aberrant DNA methylation. DNAs from 44 fresh tumor

Obesity and esophageal cancer: GERD, Barrett´s esophagus, and molecular carcinogenic pathways

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Introduction: Increases in the rates of esophageal adenocarcinoma (EAC) have paralleled rises in the prevalence of overweight and obesity. Despite not being fully understood, obesity-related EAC seems to have different carcinogenic pathways.

Incidence and outcomes of chemotherapy and radiation in morbidly obese patients with locally advanced lung and esophageal cancers: a single-institution experience.

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BACKGROUND In 2012, the American Society of Clinical Oncology issued a guideline urging health care professionals to "routinely use an obese patient's actual body weight, rather than an ideal body weight or other estimate, to calculate the appropriate dose of nearly all chemotherapy drugs. " This

Association between diabetes and esophageal cancer, independent of obesity, in the United States Veterans Affairs population.

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In the past 30 years, the incidence of esophageal adenocarcinoma (EAC) has increased more rapidly than any other cancer in the United States. The prevalence of obesity and diabetes mellitus has drastically increased as well. We explored the potential association between obesity, diabetes mellitus,

Abdominal obesity increases risk for esophageal cancer: a nationwide population-based cohort study of South Korea.

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The relationship between overall obesity, as measured by body mass index (BMI) and risk of esophageal squamous cell carcinoma (ESCC) has been reported to show a negative correlation. However, the relationship of ESCC, which accounts for around 90% of esophageal cancers in South Korea,

IGF-1 and its receptor in esophageal cancer: association with adenocarcinoma and visceral obesity.

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OBJECTIVE The insulin-like growth factor (IGF) pathway and visceral obesity have been independently linked with esophageal cancer. This study aimed to delineate the differential and interlinked role of visceral obesity and the IGF-1 system in esophageal adenocarcinoma and esophageal squamous-cell

Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers.

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Rates of adenocarcinoma of the esophagus (EAC) and esophagogastric junction (EGJAC) have been rising rapidly in recent decades, in contrast to the declining rates of esophageal squamous cell carcinomas (ESCC). Obesity is a major risk factor for both EAC and EGJAC, but not ESCC, and there is

Obesity Paradox in Esophageal Cancer: Fashion or Reality?

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Obesity and esophagectomy for esophageal cancer: is it only the high BMI that defines prognosis?

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Obesity Paradox in Esophageal Cancer: Fashion or Reality? (Reply).

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Reply to letter: obesity and esophagectomy for esophageal cancer: is it only the high BMI that defines prognosis?

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Relationship Between Visceral Obesity and Postoperative Inflammatory Response Following Minimally Invasive Esophagectomy.

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BACKGROUND Esophagectomy for esophageal cancer is one of the most invasive surgeries. However, the factors influencing postoperative systemic inflammatory response following esophagectomy have not been elucidated. Recently, visceral fat has been shown to play an important role in both chronic and

Identification of Risk Factors Associated With Postoperative Acute Kidney Injury After Esophagectomy for Esophageal Cancer.

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OBJECTIVE To identify risks factors associated with acute kidney injury (AKI) after esophageal cancer surgery. METHODS This was a retrospective study. METHODS Single academic center. METHODS Subjects with non-metastatic esophageal cancer. Patients were excluded if they were younger than 18 years and

Impact of pre-diagnosis behavior on risk of death from esophageal cancer: a systematic review and meta-analysis.

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OBJECTIVE Most people diagnosed with esophageal cancer will die from their disease, but it is not known whether survival is influenced by pre-morbid behavior. We undertook a systematic review and meta-analysis to investigate the impact of pre-diagnosis behavior on risk of death for esophageal

Esophageal cancer in Canada: trends according to morphology and anatomical location.

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BACKGROUND Esophageal adenocarcinoma has one of the fastest rising incidence rates and one of the lowest survival rates of any cancer type in the Western world. However, in many countries, trends in esophageal cancer differ according to tumour morphology and anatomical location. In Canada, incidence

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