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Page 1 od 198 rezultati
Galanin contributes to ultraviolet irradiation-induced inflammation in human skin.
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Exposure of the skin to ultraviolet (UV) irradiation causes various consequences such as inflammation and photoageing. Galanin is an active neuropeptide expressed widely in the central nervous system and peripheral tissues including the skin. Galanin promotes or inhibits inflammation in a
Antinociceptive role of galanin in the spinal cord of rats with inflammation, an involvement of opioid systems.
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The present study investigated the role of galanin in the transmission of nociceptive information in the spinal cord of rats with inflammation. Bilateral decreases in hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulation were observed after acute inflammation induced by injection
An antinociceptive role of galanin in the arcuate nucleus of hypothalamus in intact rats and rats with inflammation.
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In the arcuate nucleus of hypothalamus (ARC), galaninergic fibers form synaptic contacts with proopiomelanocortin neurons, which are involved in pain modulation. The present study assessed the role of exogenous and endogenous galanin in the modulation of nociception in the ARC of rats. The hindpaw
Involvements of galanin and its receptors in antinociception in nucleus accumbens of rats with inflammatory pain.
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This study tested the hypothesis that antinociceptive effects of galanin and its receptors in nucleus accumbens (NAc) of rats with inflammatory pain provoked by subcutaneous injection of 0.1 ml of 2% carrageenin into the sole of the rat's left hindpaw. The hindpaw withdrawal latencies (HWLs) in
Antinociception induced by galanin in anterior cingulate cortex in rats with acute inflammation.
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The present study was performed to explore the role of galanin in nociceptive modulation in anterior cingulate cortex (ACC) of rats with acute inflammation, and the changes in galanin and galanin receptor 2 (Gal R2) expressions in rats with acute inflammation. Intra-ACC injection of galanin induced
Galanin-like peptide modulates energy balance by affecting inflammatory mediators?
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Galanin-like peptide (GALP) is a neuropeptide that is thought to play a role in the regulation of energy balance. However, the effects of GALP on food intake and body weight appear to be complex. In rats, central administration of GALP initially stimulates food intake, an effect that is followed by
Induction of galanin-like peptide gene expression in the arcuate nucleus of the rat after acute but not chronic inflammatory stress.
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Galanin-like peptide (GALP) has been recently isolated from the porcine hypothalamus. The GALP mRNA is restricted to neurons in the hypothalamic arcuate nucleus (Arc) and pituicytes in the posterior pituitary gland (PP), but physiological functions of the GALP remains unclear in both areas. We
Evidence for galanin receptors in primary sensory neurones and effect of axotomy and inflammation.
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Using in situ hybridization, mRNA coding for the galanin R1 receptor (GAL-R1) was demonstrated in > 20% of all lumbar 4 and 5 dorsal root ganglion neurone profiles, mainly constituting small and medium sized neurones. Almost all of these neurones expressed CGRP mRNA as revealed by analysis of
Neuropeptides in neuropathic and inflammatory pain with special emphasis on cholecystokinin and galanin.
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Neuropeptides present in primary afferents and the dorsal horn of the spinal cord have an important role in the mediation of nociceptive input under normal conditions. Under pathological conditions, such as chronic inflammation or following peripheral nerve injury, the production of peptides and
Expression and regulation of galanin-R2 receptors in rat primary sensory neurons: effect of axotomy and inflammation.
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Using in situ hybridization, we studied galanin-R2 receptor (GAL-R2-R) mRNA in rat lumbar 5 dorsal root ganglia (DRGs) at different time points after peripheral tissue inflammation and sciatic nerve transection (axotomy). About 25% of all normal DRG neuron profiles were GAL-R2-R mRNA-positive, and
Regulation of expression of galanin and galanin receptors in dorsal root ganglia and spinal cord after axotomy and inflammation.
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Galanin can normally be detected only in a few dorsal root ganglion (DRG) neurons, but it is dramatically upregulated after peripheral nerve injury in both rat and monkey. Galanin is stored in large dense core vesicles, which after axotomy are often found close to the membrane of afferent nerve
Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli.
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Galanin is a neuropeptide expressed by sensory neurones innervating the gastrointestinal (GI) tract. Galanin displays inhibitory effects on vagal afferent signaling within the upper GI tract, and the goal of this study was to determine the actions of galanin on colonic spinal afferent function.
Release of immunoreactive galanin in the spinal cord of rats with ankle inflammation: studies with antibody microprobes.
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Antibody microprobes bearing antibodies to the carboxy-terminus of rat galanin were inserted into the spinal cords of anaesthetized normal rats and those in which ankle inflammation had been induced by the unilateral subcutaneous injection of Freund's adjuvant four to six days previously. In normal
Endogenous galanin potentiates spinal nociceptive processing following inflammation.
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We have undertaken a series of experiments using galanin null mutant mice to better define the role of endogenous galanin in spinal excitability following inflammation and in response to centrally sensitizing stimuli. We have employed a behavioural paradigm, the formalin test, as a model of tonic
Inflammation- and axotomy-induced changes in galanin-like immunoreactive (GAL-LI) nerve structures in the porcine descending colon.
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This study reports on changes caused by chemically driven inflammation and axotomy in galanin-like immunoreactive (GAL-LI) nerve structures in the porcine descending colon. The distribution pattern of GAL-LI structures was studied using the immunofluorescence technique in the circular muscle layer,
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