Determine if 68Ga-BNOTA-PRGD2 PET/CT is safe and effective method for imaging of lung cancer

Lung Cancer

Cancer patients, single intravenous bolus injection of nearly 111 MBq 68Ga-NOTA-PRGD2 on day one of the treatment period, dynamic whole-body PET/CT for determination of effective dose, kinetics of 68Ga-BNOTA-PRGD2 in blood, organs, and tumors
Healthy volunteers, single intravenous bolus injection of nearly 111 MBq 68Ga-BNOTA-PRGD2 on day one of the treatment period, dynamic whole-body PET/CT for determination of effective dose, kinetics of 68Ga-BNOTA-PRGD2 in blood and organs

68Ga-BNOTA-PRGD2

Department of Nuclear Medicine, Peking Union Medical College Hopital

68Ga-BNOTA-PRGD2 PET/CT in Healthy Volunteers and Lung Cancer Patients

Radiation Dosimetry, Plasma Pharmacokinetics, Biodistribution, Safety and Diagnostic Performance of 68Ga-BNOTA-PRGD2 in Healthy Volunteers and Lung Cancer Patients

Visual analysis will be performed by consensus reading by at least 3 experienced nuclear medicine physician. The semiquantitative analysis will be performed by the same person for all the cases, and the standardized uptake values (SUVs) of tumor and organs will be measured.

Blood pressure of healthy volunteers will be measured at three time points: right before injection, after scanning, and 24 hours after treatment.

Pulse will be measured at three time points for each healthy volunteer: right before injection, after scanning, and 24 hours after treatment.

Respiration frequency will be measured at three time points for each healthy volunteer: right before injection, after scanning, and 24 hours after treatment.

Temperature will be measured at three time points for each healthy volunteer: right before injection, after scanning, and 24 hours after treatment.

Routine blood test of healthy volunteers will be measured at two time points: right before and 24 hours after treatment.

Routine urine test of healthy volunteers will be measured at two time points: right before and 24 hours after treatment.

Serum alanine aminotransferase of healthy volunteers will be measured at two time points: right before and 24 hours after treatment.

Serum albumin of healthy volunteers will be measured at two time points: right before and 24 hours after treatment.

Serum creatinine of healthy volunteers will be measured at two time points: right before and 24 hours after treatment.

Adverse events within 5 days after the injection and scanning of healthy volunteers and patients will be followed and assessed.

glycine/albumin

68Ga-BNOTA-PRGD2 PET/CT in Healthy Volunteers and Lung Cancer Patients

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