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Smokeless tobacco use: a risk factor for hyperhomocysteinemia in a Pakistani population.

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BACKGROUND Smokeless tobacco (ST) use is highly prevalent in the South Asian populations. While there have been a number of reports on association of ST consumption with cancer, very few studies have been conducted to investigate its relationship with cardiovascular disease. Hyperhomocysteinemia is

Is hyperhomocysteinemia an additional risk factor of the metabolic syndrome?

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The aim of this study was to ascertain if hyperhomocysteinemia is associated with the metabolic syndrome. The metabolic syndrome is a cluster of cardiovascular risk factors. Hyperhomocysteinemia is an obvious independent risk factor for atheroma, and thrombosis morbidity and mortality. EPIMIL is a

Dietary patterns are associated with hyperhomocysteinemia in an urban Pakistani population.

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Little attention has been given to the association of dietary patterns with plasma homocysteine. Our objective in this study was to identify major dietary patterns and investigate their association with plasma homocysteine. In a cross-sectional survey, 872 healthy adults (355 males, 517 females;

Homocysteinemia: new information about an old risk factor for vascular disease.

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OBJECTIVE To determine the importance of homocysteinemia as a risk factor for atherosclerotic vascular disease. METHODS Literature review of published studies homocysteine as risk factor for atherosclerotic vascular disease. METHODS MEDLINE search from 1969 to 1998 using homocysteine and vascular

Hyperhomocysteinemia and recurrent carotid stenosis.

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BACKGROUND Hyperhomocysteinemia has been identified as a potential risk for atherosclerotic disease in epidemiologic studies. This study investigates the impact of elevated serum homocysteine on restenosis after carotid endarterectomy (CEA). METHODS In a retrospective study, we compared fasting

Hyperhomocysteinaemia in young patients with non-arteritic anterior ischaemic optic neuropathy.

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OBJECTIVE Elevated plasma homocysteine is a newly identified vascular risk factor among patients under age 55 years with cerebrovascular, cardiovascular, or peripheral vascular disease. This study sought to evaluate retrospectively the plasma homocysteine status among healthy younger patients with

Metabolic interactions between hyperhomocysteinemia and endothelin-1 among Tunisian patients with acute coronary diseases.

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BACKGROUND Acute coronary syndromes (ACS) are complex and polygenic diseases which are a real problem of public health. These syndromes require multidisciplinary studies to understand the pathogenesis mechanisms and metabolic interactions between different risk factors.This study aimed to explore

Hyperhomocysteinemia in bilateral anterior ischemic optic neuropathy after conventional coronary artery bypass graft: a case report.

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BACKGROUND The incidence of anterior ischemic optic neuropathy after coronary artery bypass graft procedures ranges from 1.3 to 0.25%. The mechanisms of anterior ischemic optic neuropathy after cardiovascular procedures remain undefined but many systemic and related-to-surgery risk factors could

Hyperhomocysteinemia, C677T MTHFR polymorphism and ischemic stroke in Tunisian patients.

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BACKGROUND Hyperhomocysteinaemia has been identified as a strong risk factor for ischemic stroke (IS). A point mutation in methylene tetrahydrofolate reductase (MTHFR C677T) has been associated with increased plasma homocysteine (Hcy) levels. OBJECTIVE This preliminary study aimed to investigate

Effect of folic acid and vitamins B6 and B12 on microcirculatory vasoreactivity in patients with hyperhomocysteinemia.

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OBJECTIVE Hyperhomocysteinemia (HHcy) has been identified as an independent risk factor for atherosclerotic vascular disease. The effect of high-dose folic acid or combination vitamin therapy for the treatment of HHcy on the microcirculation is unknown. The purpose of this study was to evaluate the

[Promoting effect of hyperhomocysteinemia on vascular calcification in rats].

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OBJECTIVE To explore the effect of hyperhomocysteinemia on vascular calcification and the underlying mechanism of it. METHODS Arterial calcification of Sprague-Dawley rats was induced by vitamin D3 plus nicotine. Hyperhomocysteinemia was established by feeding high methionine diet for six weeks and

[Is mild hyperhomocysteinemia an additional risk factor of the metabolic syndrome?].

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BACKGROUND Metabolic syndrome is a cardiovascular risk factors cluster and hyperhomocysteinemia an obvious independant risk factor. OBJECTIVE To ascertain if hyperhomocysteinemia is associated with the metabolic syndrome. METHODS "Epimil" is a prospective epidemiologic survey, which began by a

Methylenetetrahydrofolate reductase (C677T and A1298C) polymorphisms, hyperhomocysteinemia, and ischemic stroke in Tunisian patients.

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OBJECTIVE The present study evaluated the role of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms and correlated these results with plasma homocysteine (Hcy) levels in Tunisian ischemic stroke (IS) patients. METHODS Overall, 84 patients with IS were included and

[The prevalence of hyperhomocysteinemia in thromboangiitis obliterans. Does homocysteine play a role pathogenetically?].

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OBJECTIVE As hyperhomocysteinaemia is known to be an important risk factor in the early onset of arteriosclerotic occlusive disease and leg-vein thrombosis, we investigated the prevalence of hyperhomocysteinaemia in patients with thromboangiitis obliterans (TAO), a condition predominantly affecting

Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review.

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Hyperhomocysteinemia (HHcy) is known to increase the risk of many diseases. Factors influencing HHcy in healthy and hypertensive subjects remain under-researched. A large population-based study was conducted in 60 communities from Shenzhen, China. Responses to standardized questions on lifestyle

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