keratoconjunctivitis sicca/protease

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Association of HLA-DR4, protease inhibitor phenotypes and keratoconjunctivitis sicca with pulmonary abnormalities in rheumatoid arthritis.

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One-hundred rheumatoid arthritis (RA) patients were assessed for the association of HLA-DR4, protease inhibitor (Pi) phenotype and keratoconjunctivitis sicca (KCS) with a variety of clinical features, airflow obstruction and bronchial reactivity. Spirometry, lung volume and gas transfer factor

Biochemical analysis of ocular surface mucin abnormalities in dry eye: the canine model.

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This study examines the canine model of keratoconjunctivitis sicca (KCS, 'dry eye') in order to establish the biochemical basis of altered ocular mucin secretion in this condition. It follows a previous examination of ocular mucins in the normal dog. Mucus was collected by suction from the ocular

High resolution computed tomography of the lung in lifelong non-smoking patients with rheumatoid arthritis.

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OBJECTIVE To define pulmonary involvement on high resolution computed tomography (HRCT) of the thorax in lifelong non-smoking rheumatoid arthritis patients and to relate the results to pulmonary function, bronchial reactivity, and a variety of clinical and serological factors. METHODS Twenty

[A case of Sjögren's syndrome and systemic sclerosis complicated with acute pancreatitis].

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We report a case of Sjögren's syndrome (SS) and systemic sclerosis (SSc) complicated with acute pancreatitis. A 51-year-old woman had been diagnosed as SS in 1973. She noticed Raynaud's phenomenon in 1977. In 1988, interstitial pneumonia (IP) was pointed out and she was treated with

Antiinflammatory therapy for dry eye.

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OBJECTIVE To present evidence establishing the relationship between inflammation and dry eye and supporting the use of antiinflammatory therapy for dry eye. METHODS Analysis of literature. METHODS Research studies that evaluated inflammation in dry eye pathogenesis and clinical trials of

Autologous serum eyedrops for dry eyes and epithelial defects: clinical and in vitro toxicity studies.

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OBJECTIVE Autologous serum drops have been reported to be beneficial in keratoconjunctivitis sicca (KCS) and persistent epithelial defects (PED). A clinical pilot study was carried out to examine these potential uses and in vitro toxicity testing on corneal epithelial cell cultures was performed to

Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease.

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OBJECTIVE To compare the expression of the pro- and anti-inflammatory forms of interleukin (IL)-1 in the tear fluid and conjunctival epithelium of normal eyes and those with dry-eye disease. METHODS The concentrations of IL-1 alpha, IL-1 beta (precursor and mature forms), and IL-1 receptor

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