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Citrus aurantium and Rhodiola rosea in combination reduce visceral white adipose tissue and increase hypothalamic norepinephrine in a rat model of diet-induced obesity.

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Extracts from the immature fruit of Citrus aurantium are often used for weight loss but are reported to produce adverse cardiovascular effects. Root extracts of Rhodiola rosea have notable antistress properties. The hypothesis of these studies was that C aurantium (6% synephrine) and R rosea (3%

Intracarotid glucose induced norepinephrine response and the development of diet induced obesity.

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Intracarotid glucose infusions cause increased plasma norepinephrine (NE) levels in some rats. This is used as an index of sympathetic activation. Similar increases in plasma NE levels are produced by intravenous glucose injections and these levels correlate positively with the amount of weight

Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice.

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Although originally developed as an antidepressant, long-term bupropion (BUP) treatment was recently shown to cause 5-8% weight loss over placebo in clinical trials with obese adults. BUP's antidepressant properties probably stem from its ability to increase extracellular brain dopamine (DA) and

Norepinephrine Dosing in Obese and Nonobese Patients With Septic Shock.

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BACKGROUND Whether or not norepinephrine infusions for support of hemodynamic status in patients with septic shock should be weight based is unknown. This situation is particularly pertinent in patients who are extremely overweight or obese. OBJECTIVE To compare dosing requirements and effect of

Evaluating the impact of obesity on safety and efficacy of weight-based norepinephrine dosing in septic shock: A single-center, retrospective study.

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OBJECTIVE Norepinephrine is the first-line vasopressor recommended for patients in septic shock. Weight-based dosing may increase drug exposure and the risk of adverse effects in obese patients. The objective was to evaluate the safety and efficacy of weight-based norepinephrine dosing using actual

Glucose-induced norepinephrine levels and obesity resistance.

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The value of glucose-stimulated sympathetic activation in differentiating rats that would subsequently resist or develop diet-induced obesity (DIO) when chronically fed a high-calorie diet (CM) enriched in fat and sucrose was tested in 3-mo-old male Sprague-Dawley rats. While the rats were on chow

Fenfluramine lowers plasma norepinephrine in overweight subjects.

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The effect of fenfluramine on sympathetic nervous system activity was determined in 12 normotensive, obese men. Supine plasma norepinephrine (NE) concentrations decreased (p less than 0.001) from pretherapy levels (298 +/- 39 pg/ml) after one (166 +/- 30 pg/ml) and four weeks (171 +/- 28 pg/ml) of

The metabolic effect of thyrotropin releasing hormone (TRH) and norepinephrine (NE) in cold-acclimated obese rats.

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We have studied the effects of chronic peripheral infusion of thyrotropin releasing hormone (TRH) and norepinephrine (NE) alone and together. Do these hormones additively affect energy balance and body weight similarly in obese animals? 20 obese (fa/fa) Zucker strain rats were studied. Food intake,

The metabolic effect of thyrotropin releasing hormone (trh) and norepinephrine (ne) in warm-acclimated obese rats - biomed 2011.

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Thyrotropin releasing hormone (TRH) potentiates the metabolic effect of norepinephrine (NE) in warm-acclimated lean and obese rats.

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We have studied the effects of chronic peripheral infusion of thyrotropin releasing hormone (TRH) and norepinephrine (NE) alone and together. Do these hormones additively affect energy balance and body weight similarly in lean and obese animals? 20 each lean Wistar and obese (fa/fa) Zucker strain

Blunted norepinephrine responsiveness to changing energy states in obese subjects.

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We have previously reported in lean subjects a significant relationship between plasma norepinephrine metabolism and energy state. The present study has examined in six obese men the response in plasma norepinephrine flux to ten day periods of overeating (+ 1000 kcal/m2 above isocaloric

Norepinephrine turnover in obese mice and rats.

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The possibility that sympathetic nervous system activity, as assessed by measurement of norepinephrine turnover, in brown adipose tissue of animals with a predisposition for development of obesity is altered has been examined. Evidence is provided to indicate that ob/ob mice, fa/fa rats and rats

Reproducibility patterns of plasma norepinephrine and muscle sympathetic nerve traffic in human obesity.

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OBJECTIVE The present study was designed to assess the reproducibility of the two markers of adrenergic drive, venous plasma norepinephrine and efferent postganglionic muscle sympathetic nerve traffic (MSNA) in reflecting the sympathetic activation characterizing the obese state in human

Impact of Norepinephrine Weight-Based Dosing Compared With Non-Weight-Based Dosing in Achieving Time to Goal Mean Arterial Pressure in Obese Patients With Septic Shock.

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Obesity presents a growing challenge in critically ill patients because of variable medication pharmacokinetics and pharmacodynamics. Vasopressors used in the treatment of septic shock, including norepinephrine, are dosed using weight-based (WB) or non-weight-based (NWB) strategies. Retrospective

Effect of diet on energy expenditure and plasma norepinephrine in lean and obese Pima Indians.

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To assess whether thermogenesis or sympathetic nervous system (SNS) function might differ between lean and obese human subjects, studies of thermic and sympathetic responses to standard stimuli were undertaken in Pima Indians, an ethnic group with a high prevalence of obesity. Plasma levels of

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