ovarian cysts/protease

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Collagenases (MMP-1, -8 and -13) and trypsinogen-2 in fluid from benign and malignant ovarian cysts.

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Proteolytic enzymes, such as matrix metalloproteinases (MMPs) and tumor-associated trypsinogens (TAT), play a pivotal role in tumor invasion and metastasis. Among MMPs, the interstitial collagenases (MMP-1, -8 and -13) can initiate collagenolysis. In this study, we have studied the levels of MMP-1,

[Placental protein 5 and pregnancy zone protein in ovarian cysts and benign cystic ovarian tumors].

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Placental protein 5 (PP 5), a serine protease inhibitor, was measured by radioimmunoassay in benign ovarian cyst fluids, especially in follicular and luteal fluids. PP 5 was detectable in 12 out of 29 cystic fluids; the levels ranging from greater than 1.0 to less than 100 micrograms/l. PP 5 was not

Same day drainage and removal of a giant ovarian cyst.

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OBJECTIVE An unusual case of a giant ovarian cyst was successfully anaesthetized with a combination of epidural followed by general anaesthesia. The method was chosen to avoid circulatory depression and re-expansion pulmonary oedema in removal of a giant tumour in a woman who did not understand the

Use of serum secretory leukocyte protease inhibitor levels in patients to improve specificity of ovarian cancer diagnosis.

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OBJECTIVE To assess the clinical relevance of serum secretory leukocyte protease inhibitor (SLPI) levels in distinguishing patients with ovarian cancers from those with benign ovarian cysts, we determined concentrations with reference to the FIGO stage and other clinical

Placental protein 5 in benign and malignant ovarian cyst fluids.

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Placental protein 5 (PP5), a serine protease inhibitor, was measured by radioimmunoassay in fluids aspirated from benign and malignant cystic ovarian tumours. PP5 was found in 7 out of 9 malignant and in 12 out of 29 benign cyst fluids (p less than 0.01), the levels ranging from 3.0 to 73.4

Plasminogen activators are involved in angiostatin generation in vivo in benign and malignant ovarian tumor cyst fluids.

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In many tumor types, angiogenesis is the net result of pro- and anti-angiogenic mediators and correlated with metabolic activity, growth, and degree of malignancy. One of the first discovered anti-angiogenic compounds is angiostatin, a proteolytic fragment of plasminogen. The requirements for in

The balance between extracellular cathepsins and cystatin C is of importance for ovarian cancer.

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BACKGROUND A major step in cancer formation involves the degradation of the extracellular matrix, mediated by multiple degradative actions of (lysosomal) proteases. Extracellular release of lysosomal proteases (cathepsins) and their inhibitors has been associated with the development and progression

Purification and characterization of an endo-beta-galactosidase produced by Diplococcus pneumoniae.

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An endo-beta-galactosidase acting on blood group A and B substances was found in the culture fluid of Diplococcus pneumoniae. The enzyme was purified 1000-fold, and its properties were studied in detail. The enzyme preparation, thus obtained, was practically free from various exoglycosidases,

Production and characterization of monoclonal antibody to a 60-kD glycoprotein in ovarian carcinoma.

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Monoclonal IgG1 antibodies 2C8 and 2F7, derived by immunization of mice with a glycoprotein-enriched fraction of human ovarian adenocarcinoma, recognized a 60 kD glycoprotein in the ovarian tumor but not in normal ovary. Survey of other normal adult tissues by an indirect solid-phase

[HE4 and CA125 in ovarian cancer].

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BACKGROUND Ovarian cancer is forth reason that causes mortality in women all over the world. In Europe the death is 3.6 up to 9.3 in 100000 women. HE4 is a newly, more specific diagnostic marker for ovarian cancer. Human epididimis protein 4 (HE4) belongs to a group with four disulfide core

Enhanced expression of TACE contributes to elevated levels of sVCAM-1 in endometriosis.

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OBJECTIVE Are increased sVCAM-1 and sICAM-1 levels associated with tumor necrosis factor-alpha-converting enzyme (TACE) activity in endometriosis? UNASSIGNED Here we provide the first functional evidence that induced TACE activity in human endometriotic epithelial cells is at least in part

Modified immunoradiometric assay of parathyroid hormone-related protein: clinical application in the differential diagnosis of hypercalcemia.

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We have developed a sensitive, specific solid-phase immunoradiometric assay (IRMA) of parathyroid hormone-related protein (PTH-RP) with use of affinity-purified polyclonal immunoglobulins. Antibodies recognizing PTH-RP(37-74) are immobilized to a polystyrene bead to "capture" analytes from the

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