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5 rezultati
[Comparative assessment of antioxidant activity of para-aminobenzoic acid and emoxipin in retina].
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Effect of para-aminobenzoic acid (PABA) on lipid peroxidation (LPO) in rat and guinea pig retina exposed to hypoxic hypoxia is studied. PABA was injected intraperitoneally and parabulbarly before and after hypoxic exposure. Antioxidant activities of PABA and emoxipin were compared. An
Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors.
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A structure-activity relationship study of hypoxia inducible factor-1α inhibitor 3-aminobenzoic acid-based chemical probes, which were previously identified to bind to mitochondrial malate dehydrogenase 2, was performed to provide a better understanding of the pharmacological effects of LW6 and its
In Vivo Imaging of Hypoxia Associated with Inflammatory Bowel Disease by Cytoplasmic Protein-Powered Fluorescence Cascade Amplifier.
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Accurate and sensitive imaging of hypoxia associated with inflammatory bowel disease (IBD) is significant for precise diagnosis and treatment of this disease, but it remains a challenge for traditional hypoxia-activatable fluorescence probes because of more moderate hypoxic state during IBD than
[Comparative evaluation of the antioxidant activity of para-aminobenzoic acid and emoxipin in the cornea and crystalline lens (an experimental study)].
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Antioxidant effect of paraaminobenzoic acid (PABA) in the retina upon different routes of its administration has been revealed previously. In this study we investigated the antioxidant effect of PABA in the cornea and lens of rats after its parabulbar injection. Antioxidant activity of PABA was
[Synthesis of 3-[4-[(3-alkylamino-2-hydroxy)propoxy]phenyl (benzyl)]-substituted 4(3H)-quinazolines as antimyocardial ischemic agents].
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In order to search for effective antimyocardial ischemic agents, fourteen new 3-[4-[(3-alkylamino-2-hydroxy)propoxy]phenyl(benzyl)]-substituted 4(3H)-quinazolinones (II) were synthesized. Substituted o-aminobenzoic acids used as the starting materials were allowed to react with acetic anhydride and
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