pachygone dasycarpa/alkaloid

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Additional alkaloids of Pachygone ovata.

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Pachygone ovata (Menispermaceae), indigenous to the sandy seashores of southern India, is a woody climber whose fruits have been used as a rodenticide and fish poison. Chromatography of the extract of the roots resulted in the reisolation of the alkaloids liriodenine, coclaurine, trilobine (1), and

(+)-Angchibangkine, a new type of bisbenzylisoquinoline alkaloid, and other dimers from Pachygone dasycarpa.

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Analysis of the alkaloidal fraction of the stem bark extract of Pachygone dasycarpa (Menispermaceae) resulted in the isolation of 10 known bisbenzylisoquinolines, (+)-tetrandrine, (+)-penduline, (+)-fangchinoline, (+)-atherospermoline, (+)-N-methyl-7-O-demethylpeinamine, (+)-daphnoline,

Antiplasmodial and cytotoxic activity of natural bisbenzylisoquinoline alkaloids.

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As part of an ongoing collaborative effort to discover new antimalarial agents from natural sources, we have tested 53 bisbenzylisoquinoline alkaloids for cytotoxicity against cultured mammalian cells and for antiplasmodial activity against chloroquine-sensitive and chloroquine-resistant clones of

Anti-inflammatory and antinociceptive effect of Pachygone ovata leaves.

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BACKGROUND Pachygone ovata (Poir.) Miers ex Hook. F. et Thoms (Menispermaceae) is a rich source of bioactive bisbenzylisoquinoline and aporphine alkaloids. OBJECTIVE This study investigates the in vitro and in vivo anti-inflammatory and antinociceptive potential of Pachygone ovata

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