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OBJECTIVE
To alert ophthalmologists about the hazards of poisoning with ophthalmic solutions.
METHODS
We treated an 18-year-old man who attempted suicide by drinking and self-injecting pilocarpine eyedrops. He had severe signs of parasympathomimetic poisoning.
RESULTS
Because of heavy and repeated
OBJECTIVE
The aim of the study was: (1) to confirm the action of pilocarpine hydrochloride (Salagen) against xerostomia: (2) to correlate the response to dose/volume radiotherapy parameters.
METHODS
From June 1995 to February 1996, 156 patients with severe radiation induced xerostomia received
The centrally- and peripherally-acting muscarinic cholinergic agonist pilocarpine (PILO, 0.125-1.0 mg/kg, IP) elicited a significantly increased frequency of occurrence of limb flicking at 0.25-1.0 mg/kg, and significantly increased the frequency of occurrence of other grooming behaviors, in 4-6
OBJECTIVE
To evaluate the efficacy and side effects of oral pilocarpine for the treatment of ocular symptoms in patients with primary Sjögren's syndrome (SS).
METHODS
A 12 week, single centre, randomised controlled study was performed. Twenty nine patients were randomly assigned to receive oral
Glycogen synthase kinase 3 (GSK-3) is a constitutively active multifunctional serine-threonine kinase which is involved in diverse physiological processes. GSK-3 has been implicated in a wide range of diseases including neurodegeneration, inflammation, diabetes and cancer. GSK-3 is a downstream
Published studies have shown that the transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX), has pro and antiemetic effects. RTX can suppress vomiting evoked by a variety of nonselective emetogens such as copper sulfate and cisplatin in several vomit-competent
OBJECTIVE
The authors determined the efficacy and safety of oral pilocarpine tablet in symptomatic relief of post-radiation xerostomia in head and neck cancer patients.
METHODS
Thirty-three radiation-induced xerostomia patients were enrolled in a single-blind method to receive placebo 1-tablet three
OBJECTIVE
To see whether a cholinomimetic medication would help resolve the parotid gland enlargement associated with self-induced vomiting in bulimic patients.
METHODS
The medication was administered on an inpatient eating disorder unit to bulimic patients with refractory
A 34-year-old woman was hospitalised with acute onset nausea, vomiting, ataxia, nystagmus, blurred vision, and bilateral mydriasis. Toxicologic investigations and serologic tests for infectious aetiologies were negative. Demyelinating disease was suspected based on magnetic resonance imaging (MRI)
The dihydropyridine l-type calcium (Ca(2+)) channel blockers nifedipine and amlodipine reduce extracellular Ca(2+) entry into cells. They are widely used for the treatment of hypertensive disorders. We have recently demonstrated that extracellular Ca(2+) entry via l-type Ca(2+) channels is involved
In eating disorders, such as bulimia nervosa, body image disturbance often extends beyond the realm of weight and shape into the dermatologic spectrum. While commonly associated conditions due to binging and self-induced vomiting include cutaneous entities (e.g., Russell's sign, acne, alopecia and
BACKGROUND
Botulism is currently an uncommon disease in which the botulinum toxin causes a progressive muscular paralysis that can lead to the death due to a failure of respiratory muscles.
METHODS
Two brothers, both addicted to cocaine, came to the casualty department because of a decrease of near
A 7-year-old girl presented with bilaterally dilated pupils, nausea, and vomiting 2 days after head trauma. Pilocarpine pupil testing led to the correct diagnosis of pharmacologic pupillary dilation from an unexpected and unusual source of plant poisoning, Solanum dulcamara (blue nightshade). In
To report a unique case of acute angle closure glaucoma in the setting of a subarachnoid hemorrhage due to a ruptured cerebral aneurysm.Observational case report and review of the literature.A 75-year-old woman presented with