pyroglutamic acid/diabetes mellitus

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Maternal Early Pregnancy Serum Metabolites and Risk of Gestational Diabetes Mellitus.

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BACKGROUND Significant gaps remain in the understanding of genetic and environmental risk factors, as well as related mechanisms that contribute to gestational diabetes mellitus (GDM). OBJECTIVE This study aimed to investigate early pregnancy maternal serum metabolites and subsequent risk of

Anti-diabetic effect of pyroglutamic acid in type 2 diabetic Goto-Kakizaki rats and KK-Ay mice.

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With the rapidly increasing prevalence of type 2 diabetes mellitus (T2DM), specific dietary components with anti-diabetic efficacy could be one strategy with therapeutic potential. In the present study, the anti-diabetic effects of an amino acid, pyroglutamic acid (PA), found in vegetables and

Fasting serum α‑hydroxybutyrate and pyroglutamic acid as important metabolites for detecting isolated post-challenge diabetes based on organic acid profiles.

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The aim of this study was to develop a method to detect serum organic acid profiles in patients with isolated post-challenge diabetes (IPD) and to compare the metabolites between IPD patients, type 2 diabetes mellitus (T2DM) and healthy controls. We developed a gas chromatography-mass spectrometry

Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics.

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OBJECTIVE Metabolic profiling of small molecules offers a snapshot of physiological processes. To identify metabolic signatures associated with type 2 diabetes and impaired fasting glucose (IFG) beyond differences in glucose, we used mass spectrometry-based metabolic profiling. METHODS Individuals

A metabolic profiling strategy for biomarker screening by GC-MS combined with multivariate resolution method and Monte Carlo

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A GC-MS based metabolic profiling method via a multivariate resolution method and Monte Carlo PLS-DA is proposed for screening potential biomarkers, and applied to Type 2 diabetes mellitus. The metabolic profiles of plasma samples from healthy control and Type 2 diabetes mellitus patient groups were

Plasma metabolites associated with arterial stiffness in patients with type 2 diabetes

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Background: Although an increased arterial stiffness has been associated with traditional coronary risk factors, the risk factors and pathology of arterial stiffness remain unclear. In this study, we aimed to identify the plasma

5-Hydroxyhexanoic Acid Predicts Early Renal Functional Decline in Type 2 Diabetes Patients with Microalbuminuria.

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Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Microalbuminuria (MA) is widely used to predict early progressive renal function decline (ERFD) of DN in type 2 diabetes mellitus (T2D) patients, but the sensitivity and specificity of MA have been questioned.

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