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Production of ascorbate and hydroxyl radicals in the liver of LEC rats in relation to hepatitis.

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The production of radicals was examined in vitro in liver supernatant prepared from LEC rats of different ages before and after the onset of jaundice. Each liver supernatant was subjected to heat-treatment at 90 degrees C for 10 min to remove heat-labile proteins, and then the production of radicals

Unusual generation of hydroxyl radicals in hepatic copper-metallothionein of LEC (Long-Evans cinnamon) rats in the presence of hydrogen peroxide.

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A mutant strain of LEC rats (Long-Evans rats with a cinnamon-like coat color) develop spontaneous hepatic injury associated with severe jaundice about 4 months after birth. Recently, we obtained evidence which shows an unusual accumulation of copper (Cu) in the liver of LEC rats, followed by the

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