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Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans.
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Increasing epidemiological evidence supports the view that dietary flavonoids have protective roles in oral diseases, including cancer. However, the dietary forms of flavonoids, the flavonoid glycosides, must first be hydrolyzed to the aglycones, which is thought to occur mainly in the intestine. In
The effects of selected dietary bioflavonoid supplementation on dental caries in young rats fed a high-sucrose diet.
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Recent evidence suggests that certain bioflavonoids reduce dental caries and cariogenic bacteria incidence. The present study evaluates two separate, but related, dietary trials -- trial 1, 0.09%, 0.18%, 0.36%, and 0.72% dietary naringenin (NAR) supplementation; and trial 2, 0.57% dietary rutin (R),
Activation of rutin by human oral bacterial isolates to the carcinogen-mutagen quercetin.
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Oral streptococci, isolated from the mouths of 2 healthy subjects, hydrolysed innocuous rutin, a flavonoid glycoside, to its genotoxic aglycon quercetin, in vitro. The isolates were identified as Streptococcus milleri. The glycosidase, rutinase, was studied in cell-free extracts derived from one of
Flavonoid Glycosides Inhibit Sortase A and Sortase A-Mediated Aggregation of Streptococcus mutans, an Oral Bacterium Responsible for Human Dental Caries.
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Three flavonoids were isolated from dried flowers of Sophora japonica using repetitive column chromatography and high-performance liquid chromatography. The flavonoids were identified as rutin (1), quercetin-3'-O-methyl-3-O-α-L-rhamnopyranosyl(1 → 6)-β-D-glucopyranoside (2), and quercetin (3) on the
Channel directed rutin nano-encapsulation in phytoferritin induced by guanidine hydrochloride.
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Phytoferritin cage has a nano-sized cavity to encapsulate bioactive molecules. In this work, a novel approach is presented that guanidine hydrochloride (GuHCl) (2mM) can expand the channel of apo-soybean seed ferritin (apoSSF) and promote the encapsulation of rutin molecules in apoSSF at pH 7.0
Modulation of reactive oxygen species production, apoptosis and cell cycle in pleural exudate cells of carrageenan-induced acute inflammation in rats by rutin.
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The present study seeks to investigate the effect of rutin, a flavonoid compound in rat models of acute inflammation induced by carrageenan (CAR). Twenty-four female Wistar rats weighing 222-247 g received saline or 2% λ-carrageenan in the pleural cavity and treatment with rutin (80 mg kg-1) or
Boronic acid based imprinted electrochemical sensor for rutin recognition and detection.
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Multi-walled carbon nanotubes (MWNTs) and boronic acid based molecular imprinting polymer (MIP) were successively modified on a glassy carbon electrode surface to fabricate a novel electrochemical sensor for rutin recognition and detection. 3-Aminophenylboronic acid (APBA) was chosen as a monomer
New Patent on Electrospinning for Increasing of Rutin Loading in Nanofibers.
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An investigation into the supramolecular structure, solubility, stability and antioxidant activity of rutin/cyclodextrin inclusion complex.
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The formation of supramolecular inclusion complexes between rutin and four cyclodextrins, namely β-cyclodextrin (β-CD), (2-hydroxypropyl)-α-cyclodextrin (HP-α-CD), (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD) and (2-hydroxypropyl)-γ-cyclodextrin (HP-γ-CD), and the effects of the complexation on the
The rutin/beta-cyclodextrin interactions in fully aqueous solution: spectroscopic studies and biological assays.
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In the present work the feasibility of beta-cyclodextrin complexation was explored, as a tool for improving the aqueous solubility and antioxidant efficacy of rutin. By means of 1H NMR, UV-vis and circular dichroism spectroscopy the single aromatic ring of rutin was found to be inserted into the
Influence of flavonoids on long-term bonding stability on caries-affected dentin
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Objectives: To evaluate the effect of experimental dentin pre-treatment solutions formulated with different flavonoids on microtensile bond strength (μTBS), nanohardness (NH) and ultra-morphological characteristics of artificial
Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.
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We evaluated the antifilarial activity of 6 flavonoids against the human lymphatic filarial parasite Brugia malayi using an in vitro motility assay with adult worms and microfilariae, a biochemical test for viability (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT)-reduction
Beyond organoleptic characteristics: the pharmacological potential of flavonoids and their role in leukocyte migration and in L-selectin and β2-integrin expression during inflammation.
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Flavonoids are compounds responsible for several organoleptic characteristics of plant-derived foods. They are also bioactive compounds with antiinflammatory role. Different mechanisms for this activity have been reported, but their effects on cell migration are not fully understood. In the present
Simultaneous determination of flavonoid analogs in Scutellariae Barbatae Herba by β-cyclodextrin and acetonitrile modified capillary zone electrophoresis.
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A capillary zone electrophoresis (CZE) method modified by β-cyclodextrin (β-CD) and acetonitrile (ACN) was developed for simultaneous determination of seven structurally similar flavonoids in Scutellariae Barbatae Herba (SBH) and its preparations. Molecular selectivity of the analytes by β-CD was in
β-Cyclodextrin-modified three-dimensional graphene oxide-wrapped melamine foam for the solid-phase extraction of flavonoids.
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A new three-dimensional graphene oxide-wrapped melamine foam was prepared and used as a solid-phase extraction substrate. β-Cyclodextrin was fabricated onto the surface of three-dimensional graphene oxide-wrapped melamine foam by a chemical covalent interaction. In view of a specific surface area
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