salicin/fever

Pharmacokinetic and pharmacological studies were performed to compare the antipyretic effects of salicin (SL), saligenin (SG, an aglycone of SL) and salicylic acid (SA, an active metabolite of SL) in rats. When SL was administered orally to rats, SA appeared slowly in the plasma and levels increased

[From the plant to chemistry--the early history of "rheumatic medication"].

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The empirical administration of medication of plant, animal and even mineral origin goes back thousands of years. It was only in the 19th century that such therapy gained a scientific basis by means of the possibility to extract the active substances and analyze them chemically, and ultimately

Identification of phase-II metabolites from human serum samples after oral intake of a willow bark extract.

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Willow bark (Salicis cortex) is a herbal medicinal drug used to treat fever and pain, such as headaches and lower back pain. Until now, it has not been fully understood which compounds are responsible for the efficacy of the drug.Although salicylic acid is

A chemically defined 2,3-trans procyanidin fraction from willow bark causes redox-sensitive endothelium-dependent relaxation in porcine coronary arteries.

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Extracts of the bark of willow species (Salix spp.) are popular herbal remedies to relieve fever and inflammation. The effects are attributed to salicin and structurally related phenolic metabolites, while polyphenols including procyanidins are suggested to contribute to the overall effect of willow

Perthshire pioneer of anti-inflammatory agents (Thomas John Maclagan).

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The achievements of Thomas John Maclagan (1838-1903) include the first specific use of salicin to cure acute articular rheumatism. He began salicin treatment in 1874 in Dundee, where he was a medical practitioner from 1869 to 1879. Maclagan was also the resident medical superintendent at Dundee

Salix alba (white willow) medicinal plant presents genotoxic effects in human cultured leukocytes.

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Salix alba (SA), commonly known as white willow, is a plant used in folk medicine for the treatment of chronic and acute inflammation, infection, pain, and fever. The phytochemical characterization of the bark extract of this plant indicated that its main component is salicin, a precursor of

Characterisation and antibiotic susceptibilities of Streptobacillus moniliformis.

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The characteristics of seven strains of Streptobacillus moniliformis, including four isolates from a recent outbreak of Haverhill fever, are reported. Acid production from carbohydrates was uniform apart from variable reactions with mannose and salicin. Enzymatic reactions determined by the API ZYM

[The Italian contributions to the history of salicylates].

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It is well-known that the modern history of salicylates began in 1899 when the compound acetylsalicylic acid was registered and introduced commercially as "aspirin" by the Bayer Company of Germany. As a matter of fact, however, remedies made from willow bark had been used to treat fever and

Hernquist's Animal Pharmacy--can any of the drugs sold there in the eighteenth century be of use to day?

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Carl von Linné's 300th birthday is celebrated this year (2007) in Sweden. One of his pupils, Peter Hernquist, has also been acknowledged and an exhibition on his Veterinary Pharmacy has been presented in Skara, Sweden. Some of the drugs sold in this pharmacy are discussed. Thus chamomile prescribed

Variations in the chemical composition and content of salicylic glycosides in the bark of Salix purpurea from natural locations and their significance for breeding.

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Willow bark is one of the few plant raw materials which contain natural active substances that have analgesic, fever-reducing, anti-inflammatory and anti-rheumatic effects. Salix purpurea, listed as widespread and common in many countries, belongs to the willow species with the highest content of

[From willow bark to acetylsalicylic acid].

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Acetylsalicylic acid is one of the most widely used drugs in the world. Its ancestry the salicylates, including salicin and salicylic acid, are found in the bark and leaves of the willow and poplar trees. The ancient Sumerians and Egyptians, as well as Hippocrates, Celsus, Pliny the Elder,

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