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4 rezultati
[Effects of silybin on acute myocardial infarction and reperfusion injury in anesthetized rats].
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The effects of silybin (Sil) on myocardial infarction size and ischemia- and reperfusion-induced arrhythmias were studied in anesthetized open chest Sprague-Dawley rats. It was found that pretreatment with Sil 20, 50, and 80 mg.kg-1 iv reduced significantly infarct size by 34.7%, 35.0%, and 50.6%
Protective effects of silybin and tetrandrine on the outcome of spontaneously hypertensive rats subjected to acute coronary artery occlusion.
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The effects of silybin and tetrandrine on the survival of spontaneously hypertensive rats subjected to acute coronary artery occlusion were investigated. The mortality after acute coronary occlusion in spontaneously hypertensive rats (66.7%) was higher than that of control Wistar-Kyoto rats (20%, P
Neuroprotective effect of pAkt and HIF-1 α on ischemia rats.
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OBJECTIVE
To explore the neuroprotective effect of pAkt and HIF-1 α on ischemia rats.
METHODS
The rat model of cerebral ischemia which induced by permanent middle cerebral artery occlusion was established, Silybin were given respectively. The behavior was measured by modified Longa method, brain
Inhibitory Effect of Flavonolignans on the P2Y12 Pathway in Blood Platelets.
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Adenosine diphosphate (ADP) is the major platelet agonist, which is important in the shape changes, stability, and growth of the thrombus. Platelet activation by ADP is associated with the G protein-coupled receptors P2Y1 and P2Y12. The pharmacologic blockade of the P2Y12 receptor significantly
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