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Biochemical and histological changes produced by sweeteners and cytarabine in the brain of young rats.

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OBJECTIVE The aim of this study was to evaluate the effect of splenda and stevia on dopamine and 5-HIAA levels, and some biomarkers of oxidative stress in the presence of cytarabine. METHODS Forty-eight young male Wistar rats each with a weight of 80 g (four weeks of age), distributed in six groups

Neuroprotective and Ameliorating Impacts of Omega-3 Against Aspartame-induced Neuronal and Astrocytic Degeneration.

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Aspartame (ASP) is one of the commonest artificial sweetener used all over the world and considered as an extremely risky compound and raises a lot of controversy. Therefore, this study was designed to investigate cellular damage of the anterior horn cells in the spinal cord of albino male rats and

Acute toxicity of stevioside, a natural sweetener, and its metabolite, steviol, in several animal species.

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The acute toxicity of stevioside and steviol (a product of enzymatic hydrolysis of stevioside) was investigated in three animal species including rat, mouse and hamster. The susceptibility to stevioside and steviol acute toxicity in both sexes of these animal species was compared. The animals were

A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension.

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OBJECTIVE Stevioside is a natural plant glycoside isolated from the plant Stevia rebaudiana which has been commercialized as a sweetener in Japan for more than 20 years. Previous animal studies have shown that stevioside has an antihypertensive effect. This study was to designed to evaluate the

Spatial Models of Sewer Pipe Leakage Predict the Occurrence of Wastewater Indicators in Shallow Urban Groundwater.

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Twentieth century municipal wastewater infrastructure greatly improved U.S. urban public health and water quality. However, sewer pipes deteriorate, and their accumulated structural defects may release untreated wastewater to the environment via acute breaks or insidious exfiltration. Exfiltrated

Processing of Coconut Sap into Sugar Syrup using Rotary Evaporation, Microwave and Open-Heat Evaporation Techniques.

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Coconut sugar has caramel colour with taste like brown sugar is commonly used as natural sweetener. However, coconut sugar was generally produced from coconut sap using a traditional method which is by heating the sap at high temperature (>100°C) in an open pan for long hours (3-5

Yoghurt and dairy snacks presented for sale to an Australian consumer: are they becoming less healthy?

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OBJECTIVE To assess the nutrient profile of yoghurts and dairy desserts. METHODS Nutrition information panels and product labels on yoghurts and dairy desserts offered for sale were surveyed in 2005 and 2008 and nutrients analysed by two nutrient profiling systems. METHODS A large supermarket in

Pulsus alternans in a critically ill dog hospitalized for xylitol toxicity

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A 2-year-old spayed female Great Pyrenees cross dog was presented following the consumption of pure xylitol sweetener. Blood tests revealed hepatocellular leakage and cholestasis, hyperlactatemia, thrombocytopenia, and prolonged prothrombin and activated partial thromboplastin times. Thoracic

Administration of aspartame in non-insulin-dependent diabetics.

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A study was designed to determine the effect of the consumption of the nutritive sweetener aspartame on non-insulin-dependent diabetics. Forty-three adult diabetics between the ages of 21 and 70 completed a 90-day study; all were diabetics whose conditions were managed by diet and/or hypoglycemic

Effects of chronic aspartame consumption on MPTP-induced Parkinsonism in male and female mice.

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BACKGROUND Parkinson's disease is a progressive neurodegenerative disorder. Aspartame (l-aspartyl-l-phenylalanine methyl ester), a low calorie sweetener used in foods and beverages. OBJECTIVE This study investigated the effect of chronic aspartame intake on Parkinsonism induced by

A combined chronic toxicity/carcinogenicity study of sucralose in Sprague-Dawley rats.

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The chronic toxicity and potential carcinogenicity of sucralose was evaluated by exposing Sprague-Dawley rats to dietary concentrations of this low-calorie sweetener both in utero and for up to 104 weeks following parturition. The rats assigned to the toxicity phase of this investigation were

Effects of Ultrasound Assistance on Dehydration Processes and Bioactive Component Retention of Osmo-Dried Sour Cherries.

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Despite having numerous health benefits, dried sour cherries have proven to be more acceptable to consumers when infused with sugar or other sweeteners to enhance their flavor, which, in turn, leads to serious anthocyanin losses. For this reason, a consideration was made for the application of

Acute hepatic failure and coagulopathy associated with xylitol ingestion in eight dogs.

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METHODS 8 adult dogs were evaluated for treatment of lethargy and vomiting after ingestion of xylitol, a sugar alcohol used as a sweetener in various products. RESULTS In addition to vomiting and lethargy, 5 of the dogs had widespread petechial, ecchymotic, or gastrointestinal tract hemorrhages.

Glial-neuronal interactions underlying fructose utilization in rat hippocampal slices.

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Although fructose is commonly used as a sweetener, its effects on brain function are unclear. Using rat hippocampal slices, we found that fructose and mannose, like pyruvate, preserve ATP levels during 3-h of glucose deprivation. Similarly, fructose and mannose restored synaptic potentials

Metabolism of cyclamate and its conversion to cyclohexylamine.

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Since cyclamates were first introduced in the early 1950s, arguments have raged over the potential carcinogenicity of this artificial sweetener. Concern over the safety of cyclamates arises from observations that some individuals and experimental animals can metabolize cyclamate to cyclohexylamine

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