A new protein, termed TAP 29, obtainable from the root tuber of the plant Trichosanthes kirilowii or produced by recombinant means is useful for treating HIV infections or tumors. In treating HIV infections, the protein is administered alone or in conjunction with conventional AIDS therapies. Also provided are processes for purifying the protein, DNA sequences encoding the protein, hosts expressing the protein, recombinant DNA methods for expressing the protein, and antibodies specific for the protein.

New York University

American Biosciences, Inc.

The United States of America as represented by the Department of Health

Anti-HIV protein, TAP 29, from tricosanthes, DNA coding therefor and therapeutic uses thereof

Purified cytotoxic proteins for use within therapeutic compositions are disclosed. The proteins inhibit protein synthesis in vitro, exhibit abortifacient activity in mice, and contain proline residues with equivalent positions at residue 43 and residue 46 in ricin A-chain. A method for preparing such a cytotoxic protein from the tissue of Trichosanthes kirilowii is also disclosed. The proteins may also be used within a method for inhibiting protein synthesis in selected cells.

trichosanthes/antimikotično

Anti-HIV protein, TAP 29, from tricosanthes, DNA coding therefor and therapeutic uses thereof

Cytotoxic protein from Trichosanthes kirilowii

Novel cytotoxic protein

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