tyrosinase/glavobolja

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Fargesin inhibits melanin synthesis in murine malignant and immortalized melanocytes by regulating PKA/CREB and P38/MAPK signaling pathways.

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Fargesin is commonly used in the treatment of allergic rhinitis, inflammation, sinusitis and headache.The aim of the study is to investigate a new function of fargesin against melanin production and its underlying molecular

Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines.

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Cutaneous melanoma is least common (only about 1% of skin cancers) but is the deadliest malignant tumor. Moreover, amelanotic types of melanoma are very difficult for clinical diagnosis. The standard therapy can cause a lot of side effects, e.g., nausea, vomiting, and headaches, which means that

Glucosamine: an ingredient with skin and other benefits.

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Both glucosamine and its derivative N-acetyl glucosamine are amino-monosaccharides that serve key biochemical functions on their own and as substrate precursors for the biosynthesis of polymers such as glycosaminoglycans (e.g., hyaluronic acid) and for the production of proteoglycans. Glucosamine

Alum with interleukin-12 augments immunity to a melanoma peptide vaccine: correlation with time to relapse in patients with resected high-risk disease.

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OBJECTIVE We attempted to augment immunity to melanoma antigens using interleukin-12 (IL-12) with aluminum hydroxide (alum) for sustained release or granulocyte macrophage colony-stimulating factor (GM-CSF) added to a multipeptide vaccine. METHODS Sixty patients with high-risk resected melanoma were

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