Diabetes Mellitus

Cardiovascular Diseases

Hamad Medical Coorporation

Qatar Cardiometabolic Registry

Hamad Medical Corporation

Receives twice daily 100mg nitrofurantoin for 5 days following catheter removal

Receives twice daily matching placebo for 5 days following catheter removal

Receives twice daily 100mg nitrofurantoin for 5 days following catheter removal
Nitrofurantoin 100 MG: Patients will receive nitrofurantoin 100mg twice daily by mouth for 5 days

Nitrofurantoin

Receives twice daily matching placebo for 5 days following catheter removal
Placebo Oral Tablet: Matching placebo

Placebo

Total

Sex/Gender, Customized

Race/Ethnicity, Customized

Body Mass Index (BMI), kg/m^2

Parity

POP-Q is a measure of the degree of Pelvic Organ Prolapse present. Stage 0 is essentially no prolapse or descent of pelvic organs; higher stages indicate progressively larger degrees of prolapse. Stage 4 is the highest stage, and indicated prolapse that is equal to or greater than the total vaginal length (in cm) minus 2 cm

POP-Q Stage

Menopausal Status

Postmenopausal Hormone Use

Current Smoking

History of Recurrent UTI

Preoperative PVR Volume (mL)

Creatinine Clearance

Participants may have had more than one procedure listed

Type of Procedure

Operative Time (mins)

Estimated Blood Loss (mL)

Length of Hospital Stay (days)

Duration of Catheterization (days)

Number of participants with a urinary tract infection in the first 30 days following pelvic reconstructive surgery

Number of participants with an adverse event only related to study drug administration

Adverse Events

Compliance assessed by use of a medication diary during treatment period

Medication Compliance

Overall Study

Dina Bastawros, MD

Catheter-Associated Urinary Tract Infection

Patients will receive nitrofurantoin 100mg twice daily by mouth for 5 days

Nitrofurantoin 100 MG

Placebo Oral Tablet

Atrium Health

Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery

Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery (NAUTICA): A Randomized Controlled Trial

Dina A. Bastawros, MD

FPMRS Fellow/Junior Faculty

Once daily treatment with oral dapagliflozin (forxiga) 10mg for 12 consecutive weeks.

Once daily treatment with oral gliclazide MR 30mg for 12 consecutive weeks.

Once daily treatment with oral dapagliflozin (forxiga) 10mg for 12 consecutive weeks.
Dapagliflozin 10mg QD: Dapagliflozin 10mg once daily for 12 weeks

Dapagliflozin 10mg Once Daily

Once daily treatment with oral gliclazide MR 30mg for 12 consecutive weeks.
Gliclazide 30mg QD: Gliclazide30mg once daily for 12 weeks

Gliclazide Modified Release 30mg Once Daily

Sex: Female, Male

Ethnicity (NIH/OMB)

Region of Enrollment

Calculated from urinary and plasma inulin concentrations, GFR in ml/min

Glomerular Filtration Rate (GFR) in ml/Min

Calculated from urinary and plasma para-aminohippurate concentrations, ERPF in ml/min

Effective Renal Plasma Flow (ERPF) in ml/Min

Calculated fractional excretions with measured GFR (see above) and urinary and plasma concentrations of sodium. Fractional excretion in % of filtered sodium

Fractional Excretion of Sodium in % of Filtered Sodium

Calculated fractional excretions with measured GFR (see above) and urinary and plasma concentrations of potassium. Fractional excretion in % of filtered potassium

Fractional Excretion of Potassium in % of Filtered Potassium

Calculated fractional excretions with measured GFR (see above) and urinary and plasma concentrations of glucose. Fractional excretion in % of filtered glucose

Fractional Excretion of Glucose in % of Filtered Glucose

Calculated from measured urinary albumin and creatinin concentrations, in mg/mmol

Urinary Albumin-Creatinine Ratio in mg/mmol

NGAL (ng/mmoll) measured in urine as a marker of renal damage

Neutrophil Gelatinase-associated Lipocalin (NGAL)

KIM-1 (ng/mmol) measured in urine as a marker of renal damage

Kidney Injury Molecule-1 (KIM-1) in ng/mmol

Body Weight

Blood pressure will be measured using an automated oscillometric blood pressure device (Dinamap®) in mmHg

Systolic Blood Pressure

Erik van Bommel

Diabetes Mellitus, Type 2

Diabetic Nephropathies

Dapagliflozin 10mg once daily for 12 weeks

Dapagliflozin 10mg QD

Gliclazide 30mg QD

VU University Medical Center

Renoprotective Effects of Dapagliflozin in Type 2 Diabetes

A Randomized, Double-blind, Comparator-controlled Trial to Assess the Effect of 12-week Treatment With Dapagliflozin Versus Gliclazide on Renal Physiology and Biomarkers in Metformin-treated Patients With Type 2 Diabetes Mellitus

M.H.H. Kramer

Head of the Internal Medicine department

AstraZeneca

Patients in the intervention group will measure their blood pressure with home blood pressure monitor which is linked to a secured website. Patients will measure as recommended in the European guidelines of hypertension. This includes 2 measurements in the morning and two times in the evening on 7 consecutive days every month. The measurements of the first day will be discarded. These measurements will be forwarded to the web-based system, which will be managed by the nurse practitioner and the research doctor. At least every month patients are contacted about the state of their condition. If needed, antihypertensive medication is added of adjusted by the nurse practitioner or research doctor under the supervision of one consultant physician. Tailored lifestyle advices are given every month.

Hypertension

Patients measure their own bloodpressure and the results are shown at a secured website after USB connection of the monitor to the computer. Patients receive medication adjustments and lifestyle advices via this secured website.

urinary tract infections/nikotin

Qatar Cardiometabolic Registry

Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery

Renoprotective Effects of Dapagliflozin in Type 2 Diabetes

Web Based Interactive Treatment and Self-monitoring in Hypertension

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