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Antiproliferative activity of Vallaris glabra Kuntze (Apocynaceae).
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BACKGROUND
Our earlier study on the antiproliferative (APF) activity of leaf extracts of ten Apocynaceae species showed that leaves of Vallaris glabra possessed strong and broad-spectrum properties.
METHODS
In this study, sequential extracts of leaves, flowers and stems, and fractions and isolated
Acoschimperoside P, 2'-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra.
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Complete (1)H and (13)C NMR assignments of acoschimperoside P, 2'-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong
Cytotoxic 20,22-Dihydrodigitoxigenin Glycosides and Other Constituents of Vallaris glabra Stems.
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Ten cardiac glycosides (1-10) including six 20,22-dihydrodigitoxigenin and four gitoxigenin glycosides were isolated from the stems of Vallaris glabra together with six known triterpenoid cinnamates. Spectroscopic data of these previously undescribed compounds are reported. All
Assessment of antiproliferative and antiplasmodial activities of five selected Apocynaceae species.
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BACKGROUND
Studies have shown that the barks and roots of some Apocynaceae species have anticancer and antimalarial properties. In this study, leaf extracts of five selected species of Apocynaceae used in traditional medicine (Alstonia angustiloba, Calotropis gigantea, Dyera costulata, Kopsia
Antiproliferative and phytochemical analyses of leaf extracts of ten Apocynaceae species.
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BACKGROUND
The anticancer properties of Apocynaceae species are well known in barks and roots but less so in leaves.
METHODS
In this study, leaf extracts of 10 Apocynaceae species were assessed for antiproliferative (APF) activities using the sulforhodamine B assay. Their extracts were also analyzed
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