vitamin d deficiency/hypoxia

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Vitamin D Deficiency in Human and Murine Sepsis.

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OBJECTIVE Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and ICU mortality but causality of these associations has not been demonstrated. To determine whether sepsis and severe sepsis are associated with vitamin D deficiency and to determine whether vitamin D deficiency

Vitamin D controls resistance artery function through regulation of perivascular adipose tissue hypoxia and inflammation.

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Vitamin D deficiency in human subjects is associated with hypertension, metabolic syndrome and related risk factors of cardiovascular diseases. Serum 25-hydroxyvitamin D levels correlate inversely with adiposity in obese and lean individuals. Bioactive vitamin D, or calcitriol, exerts

Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease.

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Vitamin D deficiency is associated with asthma risk. Vitamin D deficiency may enhance the inflammatory response, and we have previously shown that airway remodeling and airway hyperresponsiveness is increased in vitamin D-deficient mice. In this study, we hypothesize that vitamin D deficiency would

Nutritional rickets and vitamin D deficiency--association with the outcomes of childhood very severe pneumonia: a prospective cohort study.

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BACKGROUND The association of rickets and vitamin D deficiency (VDD) with pneumonia is well documented, but not with its outcomes. OBJECTIVE To investigate whether rickets and VDD predict the outcomes in very severe pneumonia (VSP). METHODS A prospective cohort study conducted at Al-Sabeen hospital

Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS).

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BACKGROUND Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory distress syndrome (ARDS). Causality of these associations has never been demonstrated. OBJECTIVE To determine if

Vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea-hypopnea syndrome.

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OBJECTIVE We aimed to assess Vitamin D (VD) abnormalities in patients with severe obstructive sleep apnea-hypopnea syndrome (OSAHS), to study its association with clinical and polygraphic data, and to correlate VD levels with interleukin-17 (IL-17). METHODS Ninety-two patients with severe OSAHS were

Vitamin D deficiency downregulates TASK-1 channels and induces pulmonary vascular dysfunction

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Vitamin D (vitD) receptor (VDR) regulates the expression of several genes involved in signaling pathways affected in pulmonary hypertension (PH). VitD deficiency is highly prevalent in PH, and low levels are associated with poor prognosis. We investigated if vitD deficiency may predispose to or

Enamel Defects in Deciduous Dentition and Their Association with the Occurrence of Adverse Effects from Pregnancy to Early Childhood

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Purpose: To verify the prevalence of developmental defects of enamel (DDE) in deciduous teeth and analyse the association with adverse events that occurred during pregnancy and early childhood. Materials

Cardiomyopathy and pericardial effusion in a 7 year-old boy with beta-thalassaemia major, severe primary hypothyroidism and hypoparathyroidism due to iron overload.
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The primary cause of cardiac dysfunction in thalassemia is believed to be myocardial iron overload. Besides iron, other factors may play a role in the impairment of myocardial contractility, including prolonged heart tissue hypoxia, pericardial involvement, arrhythmias, endocrine complications and

[Hemoglobinpathy S--clinical manifestations in children in a Zairian family].
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The clinical aspects of Hemoglobinopathy S in children of a black family from Zair living in Belgrade are discussed in the paper. The parents and two brothers are heterozygous carriers for patologyc hemoglobines; those children had, sauf permanent anaemia, the crysis of dyspnea, cyanosis, cough,

Bone loss in obesity and obstructive sleep apnea: a review of literature.
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BACKGROUND Obstructive sleep apnea (OSA) is a common sleep-related respiratory disorder. It is associated with many endocrinopathies including hypogonadotropic hypogonadism, hypercortisolism, and glucose intolerance that may lead to bone loss with secondary osteoporosis. METHODS We report the case

Redox studies of the epiphyseal growth cartilage: pyridine nucleotide metabolism and the development of mineralization.
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The objective of this investigation was to examine the redox status of chondrocytes in normal and rachitic growth cartilages and to relate energy metabolism to cell maturation and the initiation of mineralization. The redox status was evaluated by chemical analysis and by microfluorimetric scanning

Hsp90 and angiogenesis in bone disorders--lessons from the avian growth plate.
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Thiram-induced tibial dyschondroplasia (TD) and vitamin-D deficiency rickets are avian bone disorders of different etiologies characterized by abnormal chondrocyte differentiation, enlarged and unvascularized growth plates, and lameness. Heat-shock protein 90 (Hsp90) is a proangiogenic factor in

Epidemiology-driven neurodevelopmental animal models of schizophrenia.
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Human epidemiological studies have provided compelling evidence that the risk of developing schizophrenia is significantly enhanced following prenatal and/or perinatal exposure to various environmental insults, including maternal exposure to stress, infection and/or immune activation, nutritional

Activation of vitamin D receptor promotes VEGF and CuZn-SOD expression in endothelial cells.
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Endothelial dysfunction associated with vitamin D deficiency has been linked to many chronic vascular diseases. Vitamin D elicits its bioactive actions by binding to its receptor, vitamin D receptor (VDR), on target cells and organs. In the present study, we investigated the role of VDR in response

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