Development of Diagnostic and Treatment Strategy for Resistant Hypertension
Paraules clau
Resum
Descripció
This study will enroll hypertensive patients who are in treatment or those who are referred from primary clinic based on inclusion or exclusion criteria. Basic clinical information, compliance with antihypertensive medications, concomitant use of other medications will be investigated and all patients will perform 24-hr ambulatory blood pressure measurement. Screening for renal artery stenosis and primary aldosteronism will be conducted. Office blood pressure will be taken every 3-6 months. Home blood pressure measurement and 24-hr ambulatory blood pressure measurement will be performed every year. The primary outcome is the newly developed MACE during the follow-up period. The secondary outcomes are newly developed target organ damage (LVH confirmed by echocardiography or EKG, carotid femoral PWV≥ 12m/s, microalbuminuria (Urine albumin-creatinine ratio ≥30 mg/g)) and decline of renal function (doubling of serum creatinine, dialysis). The follow-up period is 3 years.
Dates
| Darrera verificació: | 04/30/2018 |
| Primer enviat: | 05/02/2018 |
| Inscripció estimada enviada: | 05/27/2018 |
| Publicat per primera vegada: | 05/29/2018 |
| Última actualització enviada: | 05/27/2018 |
| Publicació de l'última actualització: | 05/29/2018 |
| Data d'inici de l'estudi real: | 02/13/2018 |
| Data estimada de finalització primària: | 02/27/2023 |
| Data estimada de finalització de l’estudi: | 02/27/2023 |
Condició o malaltia
Fase
Criteris d'elegibilitat
| Edats elegibles per estudiar | 20 Years Per a 20 Years |
| Sexes elegibles per estudiar | All |
| Mètode de mostreig | Non-Probability Sample |
| Accepta voluntaris saludables | Sí |
| Criteris | Inclusion Criteria: 1. 20 years and older 2. Office SBP>130 mmHg or office DBP >90 mmHg with 3 antihypertensive medications of different classes 3. Treated hypertensive patients with 4 antihypertensive medications of difference classes including diuretics Exclusion Criteria: 1. desired life time under 6 months due to non-cardiovascular disease (e.g. cancer, sepsis) 2. women with pregnancy or on nursing 3. within the first three months after transplantation 4. acute renal allograft rejection 5. within six months after discharge from hospitalization for acute coronary syndrome (myocardial infarction, unstable angina) or acute stroke 6. systolic heart failure (LVEF ≤40%) |
Resultat
Mesures de resultats primaris
1. Major adverse cardiac events [3 years]
Mesures de resultats secundaris
1. Progression of CKD [3 years]
2. Target organ damages [3 years]
3. Target blood pressure achievement [3 years]
