Effects of Almond Versus Pistachio on Weight Loss

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Patrocinadors

Novindiet Clinic

Col·laboradors

University of Nottingham

Tehran University of Medical Sciences

ASSAIG CLÍNIC: NCT03120455

BioSeek: NCT03120455

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Resum

The purpose of the current study is comparing the effect of almond and pistachio, as the two common types of nuts, consumption on healthy obese and overweight female who following a hypocaloric diet for 12 weeks. The secondary aim of the current study is to evaluate of these two type of nuts on other cardiometabolic risk factors.

Dates

Darrera verificació:	02/28/2018
Primer enviat:	04/14/2017
Inscripció estimada enviada:	04/14/2017
Publicat per primera vegada:	04/18/2017
Última actualització enviada:	03/27/2018
Publicació de l'última actualització:	03/28/2018
Data d'inici de l'estudi real:	06/04/2017
Data estimada de finalització primària:	11/12/2017
Data estimada de finalització de l’estudi:	01/14/2018

Condició o malaltia

Obesity

Overweight

Intervenció / tractament

Behavioral: Almond group (AG)

Behavioral: Pistachio group (PG)

Behavioral: Nut Free (NFG, CG)

Fase

Grups de braços

Braç	Intervenció / tractament
Experimental: Almond group (AG) Obese or overweight female adults will be randomly allocated to have have almond as afternoon snack while they have a hypoenergetic diet.	Behavioral: Almond group (AG) Obese or overweight female adults will be randomly allocated to have almond as afternoon snacks, while they have a hypoenergetic diet.
Active Comparator: Pistachio group (PG) Obese or overweight female adults will be randomly allocated to have have Pistachio as afternoon snack while they have a hypoenergetic diet.	Behavioral: Pistachio group (PG) Obese or overweight female adults will be randomly allocated to have Pistachio as afternoon snacks, while they have a hypoenergetic diet.
Placebo Comparator: Nut Free (NFG, CG) Obese or overweight female adults are asked to avoid all nuts, seeds, and nut products while they have a hypoenergetic diet. , as the control group.	Behavioral: Nut Free (NFG, CG) Obese or overweight female adults will be asked to avoid nuts, seeds and nut products, while they have a hypoenergetic diet.

Criteris d'elegibilitat

Edats elegibles per estudiar	18 Years Per a 18 Years
Sexes elegibles per estudiar	Female
Accepta voluntaris saludables	Sí
Criteris	Inclusion Criteria: - Must be female - Must be 18-45 years of age. - Must have Body mass index (BMI) between 27-35 kg/ m². - Must be able to have moderate exercise. - Must be interested to have weight loss. Exclusion Criteria: - Have allergy to nuts - Participating in a research project involving weight loss or physical activity in the previous six months. - Pregnancy or lactation during the previous 6 months, or planned pregnancy in the next six months. - Taking medication that could affect metabolism or change body weight. - Report heart problems, chest pain, and cancer within the last five years. - Smoking - Menopause - Diagnosis of any chronic disease such as fatty liver, cancer, chemo/radio therapy, heart disease, immune compromised conditions, abnormal thyroid hormone level.

Resultat

Mesures de resultats primaris

1. Weight [12 Weeks]

Body weight was taken to the nearest 0.1 kg using a digital calibrated scale (Omron Health Care, Hoofddorp, Netherland), whilst subjects wore light clothing and no shoes.

Mesures de resultats secundaris

1. Waist circumference [12 Weeks]

Waist circumference (WC) was measured with a rigid measuring tape and recorded to the nearest 0.5 cm. WC was measured at the smallest horizontal circumference between the ribs and iliac crest (the natural waist), or, in case of an indeterminable waist narrowing, halfway between the lower rib and the iliac crest.

2. fasting blood glucose [12 Weeks]

Fasting plasma glucose (FPG) were measured using the enzymatic colorimetric method.

3. HbA1c [12 Weeks]

Glycated hamoglobin (HbA1c) was measured by a colorimetric method after an initial separation by ion exchange chromatography (Biosystem, Barcelona, Spain).

4. HOMA-IR [12 Weeks]

Insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR), which was calculated by using the following formula HOMA-IR = [fasting insulin (mU/l) × FPG (mmol/l)]/22.5

5. lipid profiles [12 Weeks]

Biochemical analysis of the serum total cholesterol (TC), triglyceride (TG), and high-density lipoprotein (HDL) cholesterol was carried out on a Selectra E auto analyzer (Vita Laboratory, Netherlands) following standard procedures of the Pars Azmoon diagnostic kits (Iran). The LDL cholesterol was calculated using the Friedewald formula. LDL cholesterol = TC - HDL cholesterol + (TG ÷ 2.2)

6. liver function tests [12 Weeks]

AST ALT

7. Insulin [12 Weeks]

Insulin was measured by using a radioimmunoassay with 125I-labeled human insulin and a human insulin antiserum in an immunoradiometric assay (IRMA) (Biosource, Dorest, Belgium) with a gamma-counter system (Gamma I; Genesys).

Effects of Almond Versus Pistachio on Weight Loss

Paraules clau

obesitat

pistacia

pistatxer

pèrdua de pes