Allicin Bioavailability From Garlic Supplements and Garlic Foods
Paraules clau
Resum
Descripció
The bioavailability of allicin, the main active compound of garlic, from garlic supplements and garlic foods is highly questionable and unpredictable from in vitro tests, due to dependence upon alliinase activity under conditions that challenge alliinase activity (heat, gastric acid, intestinal proteases). It is likely that garlic supplement manufacturing procedures and coatings, meal conditions when supplements are consumed (high or low protein), and garlic food preparation conditions (temperature, surface area) will greatly affect allicin bioavailability. Such variability may account for some of the many conflicts seen in clinical trials on cardiovascular disease risk factors.
To resolve these issues, this study will determine the actual bioavailability of allicin from several types of garlic supplements and garlic foods under various conditions. Bioavailability will be determined by measuring the area under the 32-hour curve for breath concentrations of allyl methyl sulfide, the main metabolite allicin.
Dates
| Darrera verificació: | 10/31/2009 |
| Primer enviat: | 03/31/2009 |
| Inscripció estimada enviada: | 03/31/2009 |
| Publicat per primera vegada: | 04/01/2009 |
| Última actualització enviada: | 11/17/2009 |
| Publicació de l'última actualització: | 11/19/2009 |
| Data d'inici de l'estudi real: | 03/31/2009 |
| Data estimada de finalització primària: | 03/31/2011 |
| Data estimada de finalització de l’estudi: | 03/31/2011 |
Condició o malaltia
Intervenció / tractament
Other: 1
Dietary Supplement: 2
Fase
Grups de braços
| Braç | Intervenció / tractament |
|---|---|
| Active Comparator: 1 Positive control with 100% allicin bioavailability | Other: 1 1 gram crushed garlic in gelatin capsules, one dose once every 2-16 weeks |
| Experimental: 2 garlic powder tablet | Dietary Supplement: 2 tablets, dose to contain 1 gram of garlic powder, consume one dose once every two weeks for up to 52 weeks |
Criteris d'elegibilitat
| Edats elegibles per estudiar | 18 Years Per a 18 Years |
| Sexes elegibles per estudiar | All |
| Accepta voluntaris saludables | Sí |
| Criteris | Inclusion Criteria: - in good health (self-judged) - BMI (body mass index): 19-32 kg/m2 - not planning to move out of the area in the next year - willing to abstain from consuming garlic and onion and foods that contain them for two days prior to and during each test (diet restrictions) - able to deliver bags of breath to the research facility five times in two days - willing to eat whole wheat tuna sandwiches Exclusion Criteria: - known serious health problems: diabetes, heart disease, active neoplasms, renal or liver disease, hyper- or hypothyroidism, breathing disorders, gastroesophageal reflux disease (GERD), gastrointestinal disease (absorption interference) - known allergy to garlic or wheat - tobacco user - excessive alcohol intake (³2 drinks/day, self-reported) - unable to speak English well |
Resultat
Mesures de resultats primaris
1. Breath allyl methyl sulfide [1-32 hours]
