Brain-Induced Neurotrophic Factor Levels in Patients Undergoing Coronary Artery Bypass Surgery
Paraules clau
Resum
Descripció
Although postoperative cognitive dysfunction (POKD) is the most common neurological complication in patients undergoing coronary artery bypass grafting (CABG) surgery, its pathophysiology is still not fully understood. However, the quality of this dysfunction has not been properly measured. In addition to clinical tests, biomarkers are often used to detect the presence of POKD. In this study, it was aimed to evaluate the relationship between intraoperative and postoperative brain-derived neurotrophic factor serum levels and POKD in patients undergoing CABG surgery.
This prospective observational study is planned to include 30 adult patients aged 40-90 years. Patients with stroke history, neurodegenerative disease, seizure history, alcohol use, general anxiety, hearing deficit, unilateral carotid artery stenosis greater than 70%, and carotid artery bilateral stenosis greater than 50% will be excluded from the study.
This study aimed to determine perioperative changes in serum brain-derived neurotrophic factor levels in patients undergoing CABG surgery.
Dates
| Darrera verificació: | 12/31/2019 |
| Primer enviat: | 01/29/2020 |
| Inscripció estimada enviada: | 01/29/2020 |
| Publicat per primera vegada: | 01/30/2020 |
| Última actualització enviada: | 01/29/2020 |
| Publicació de l'última actualització: | 01/30/2020 |
| Data d'inici de l'estudi real: | 01/14/2020 |
| Data estimada de finalització primària: | 07/31/2020 |
| Data estimada de finalització de l’estudi: | 09/30/2020 |
Condició o malaltia
Intervenció / tractament
Diagnostic Test: Patients with cognitive dysfunction
Fase
Criteris d'elegibilitat
| Edats elegibles per estudiar | 40 Years Per a 40 Years |
| Sexes elegibles per estudiar | All |
| Mètode de mostreig | Non-Probability Sample |
| Accepta voluntaris saludables | Sí |
| Criteris | Inclusion Criteria: - At Least Primary School Graduates, - Not Using Drugs That May Affect Cognitive Functions, - No Alcohol Substance Use, - Without Psychiatric And Neurological Diseases Exclusion Criteria: - Uneducated Patients, - Drug Users Who May Affect Cognitive Functions (Antipsychotic, Antidepressant), - Have Alcohol And Substance Use Disorders, - Those With A History Of Central Nervous System Disease That May Cause Cognitive Dysfunction (Such As Stroke, Neurodegenerative Disease, Seizure, General Anxiety), - Hearing Deficit, - Patients With Unilateral Carotid Artery Stenosis Greater Than 70% And Bilateral Stenosis Greater than 50% Carotid Artery |
Resultat
Mesures de resultats primaris
1. Postoperative cognitive dysfunction [4 days]
