Transcranial Direct Current Stimulation of the Motor Cortex in Essential Tremor
Paraules clau
Resum
Descripció
Essential tremor (ET) is a common progressive neurological disorder and is the most common movement disorder. Worldwide , up to 5% of the population suffer from this disorder with an increased incidence with advanced age.
The proposed mechanism that underlies ET, the central oscillating network, is mainly composed of the olivocerebellar system, thalamus and motor cortex. An interruption in this circuit limits the ability of the cortex to reorganize and restore ET. a case of 76 year old female with essential tremor that disappeared following a cortico-subcortical prerolandic stroke despite complete motor recovery highlights the role of the motor cortex in the production and possible therapeutic role of the transcranial direct current stimulation.
Study design A randomized, sham-controlled, double blind and crossover study.
Study procedure:
The first visit is an inclusion visit Prior to starting the first tDCS session, the patient will be asked to fill his/her first TRG essential tremor assessment (TETRAS) scale. The physician will then quantitatively analyze the tremor on the most affected side using an accelerometer. Cathodal tDCS will be administered on the area representing the primary motor cortex and the anode over the contralateral supraorbital area. tDCS stimulation (cathodal and sham) will be done daily for 5 consecutive days during weeks 1 and 5. Each stimulation session will last 30 minutes. tDCS will be performed while the patient is at rest, without any concurrent cognitive or motor task.The two tDCS sessions will be separated by a 23 day washout period.
Patient will be asked to fill out their TETRAS at days 1 and 5 of each tDCS session (cathodal and sham), and days 12 and 19 after each tDCS session (cathodal and sham).
Accelerometer assessment of the tremor will be performed at days 1 and 5 of each tDCS stimulation session (cathodal and sham).
Dates
| Darrera verificació: | 07/31/2019 |
| Primer enviat: | 05/13/2019 |
| Inscripció estimada enviada: | 05/13/2019 |
| Publicat per primera vegada: | 05/15/2019 |
| Última actualització enviada: | 08/11/2019 |
| Publicació de l'última actualització: | 08/12/2019 |
| Data d'inici de l'estudi real: | 07/18/2019 |
| Data estimada de finalització primària: | 05/31/2021 |
| Data estimada de finalització de l’estudi: | 09/30/2021 |
Condició o malaltia
Intervenció / tractament
Device: transcranial direct current stimulation
Fase
Grups de braços
| Braç | Intervenció / tractament |
|---|---|
| Active Comparator: Active tDCs Active tDCS will be administered through a pair of conductive rubber electrodes covered by saline soaked sponges (35 cm2). The current will be delivered continuously at 2 mA for 30 min through a battery-driven constant-current stimulator. The cathode will be positioned facing the primary motor cortex area and the anode over the contralateral supraorbital area. | |
| Sham Comparator: Sham tDCS Sham stimulation will be delivered to the motor cortex using a sham tDCS device that delivers a direct current for 10 seconds at the beginning and end of tDCS to provide sensory experiences similar to active stimulation. |
Criteris d'elegibilitat
| Edats elegibles per estudiar | 18 Years Per a 18 Years |
| Sexes elegibles per estudiar | All |
| Accepta voluntaris saludables | Sí |
| Criteris | Inclusion Criteria: - Patients who fulfil the 2017 Movement society concusses statement criteria for essential tremor Exclusion Criteria: - Isolated focal tremor (voice, head) - Orthostatic tremor with a frequency of more than 12 Hz - Task and position specific tremor - Sudden onset and stepwise deterioration of tremor - History of substance abuse or dependence in the past - Co-morbid medical conditions capable of producing or enhancing tremors - Use of a medication with potential effect on tremor - History of neurological disorders, brain tumors, brain surgery or abnormal neurological examination - Epileptic disorders - Cardiac pacemakers - Metallic hardware in the head or scalp (surgical clips) - Eczema or skin abrasion at the intended site of stimulation - Currently pregnant or plan for pregnancy in the next 6 months - Patients with prior experience with tDCS - Major psychosocial problems or medical problems rendering informed consent impossible |
Resultat
Mesures de resultats primaris
1. Tremor amplitude [5 days]
Mesures de resultats secundaris
1. Functional impact of tremor [19 days]
