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An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle cell layer.Types of acanthoma include pilar sheath acanthoma, a benign follicular tumor usually of the upper lip; clear cell acanthoma, a benign tumor found most frequently on the legs; and Degos acanthoma, often confused with but unrelated to Degos disease.

In 2005, 'Acanthoma' was added to MeSH as an index term; previous indexing was 'Skin Neoplasms' (1965–2004). At that time, PubMed indexed ...