meningeal carcinomatosis/fatiga muscular

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[A Case of Carcinomatous Meningitis Due to Gastric Cancer].

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A 43-year-old man was diagnosed with gastric cancer with diaphragm invasion and multiple lymph node metastases and underwent total gastrectomy. The histological diagnosis was por2>tub2, ypT4b(diaphragm), int, INF c, ly1, v1, ypN3, yp Stage ⅢC. Three months postoperatively, computed tomography

[Carcinomatous meningitis in gastric cancer under chemotherapy-two cases].

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The development of chemotherapy to treat gastric cancer has prolonged its prognosis, and sometimes extremely rare conditions arise. This report describes two patients with carcinomatous meningitis who rapidly progressed into unconsciousness and died. A 60-year-old woman under second-line

Treatment of Leptomeningeal Metastases in a Patient with Non-Small Cell Lung Cancer Harboring EGFR T790M Mutation.

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BACKGROUND Leptomeningeal metastasis (LM) is an uncommon complication in patients with solid tumors, associated with poor survival. However, LM appears to be more frequent in lung cancer patients with EGFR mutations, posing a unique clinical challenge to treating physicians. METHODS We report the

A phase II trial of intra-cerebrospinal fluid alpha interferon in the treatment of neoplastic meningitis.

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BACKGROUND Neoplastic meningitis (NM), a metastatic complication of both primary central nervous system and systemic cancer, occurs in 1-5% of patients with known cancer. Currently available treatment options are limited and provide only modest benefit. The current study was performed to determine

Case of meningeal carcinomatosis with gastric cancer which manifested meningeal signs as the initial symptom; the palliative benefit of radiotherapy.

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A 53-year-old male presenting with anorexia, intermittent diplopia, general fatigue, headache and vertigo was admitted to our hospital. He was diagnosed as having gastric cancer by endoscopy of his upper gastrointestinal tract. Brain computed tomography (CT) showed no abnormalities, but magnetic

Carcinomatous meningitis due to gastric adenocarcinoma: A rare presentation of relapse.

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While solid tumors are less commonly associated with meningeal involvement; lung, breast and melanoma are the ones most often reported. A few case reports have included gastric carcinoma but these are rare and most often associated with systemic disease at the time of diagnosis. Here we report a

Intrathecal topotecan in adult patients with neoplastic meningitis.

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OBJECTIVE The efficacy and safety of intrathecal topotecan were assessed in patients with neoplastic meningitis (NM) by retrospective chart review. CONCLUSIONS Fourteen patients (median age, 57 years) with NM were treated with the standard of care (i.e., regional or systemic chemotherapy or

A phase I trial of recombinant interferon-alpha and alpha-difluoromethylornithine in metastatic melanoma.

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Both interferon-alpha (IFN-alpha) and alpha-difluoromethylornithine (DFMO) have shown modest activity as single-agent therapy in the treatment of malignant melanoma. Several investigators have demonstrated true synergism in vitro of the combination of DFMO and IFN-alpha against human tumor cells,

Phase II study of irinotecan and temozolomide in breast cancer patients with progressing central nervous system disease.

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PURPOSE

Breast cancer patients with progressing central nervous system (CNS) disease have limited treatment options. Few chemotherapy drugs with activity in breast cancer have well-documented CNS penetration. This phase 2 trial evaluated efficacy and safety of irinotecan 125

Phase I clinical trial of intralesional or intraventricular leukocyte interferon for intracranial malignancies.

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Eight patients were treated with leukocyte interferon for a variety of neurological malignancies that had failed or recurred after conventional therapy. Three patients with malignant astrocytoma received intratumoral interferon in dosages up to 9 million units 3X/week, with total dosages of up to

Characteristics of patients with brain metastases from lung cancer in a palliative care center.

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OBJECTIVE Patients with brain metastases present severe symptoms owing to the tumor growth or treatment side effects, and supportive measures are often critical for the patients and their families. However, there is currently a lack of palliative care and end-of-life (EoL) provision for patients

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