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Pàgina 1 des de 101 resultats
Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells.
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In rat lung and cultured lung vascular cells, hypoxia decreases ornithine decarboxylase (ODC) activity and increases polyamine import. In this study, we used rat cultured pulmonary artery endothelial cells to explore the mechanism of hypoxia-induced reduction in ODC activity and determined whether
Acute hypoxia increases ornithine decarboxylase activity and polyamine concentrations in fetal rat brain.
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The cellular responses to hypoxia are poorly understood. To test the hypothesis that ornithine decarboxylase (ODC; L-ornithine carboxy-lyase; EC 4.1.1.17) activity and polyamine concentrations change in response to acute hypoxia, we performed the following studies. Pregnant Sprague-Dawley rats
Ornithine decarboxylase activity and polyamine concentrations in fetal rat brain: response to chronic hypoxic-hypoxia and/or carbon monoxide-hypoxia.
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Ornithine decarboxylase activity (ODC; E.C. 4.1.1.17), is significantly elevated in fetal and newborn rat brain in response to acute hypoxia. Because relatively little is known about ODC activities and polyamine metabolism in hypoxia and also because ODC and the polyamines are essential for normal
[Effects of exogenous 24-epibrassinolide on the leaf photosynthetic characteristics and polyamines content of cucumber seedlings under hypoxia stress].
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A water culture experiment with 1/2 Hoagland solution was carried out to study the effects of exogenous 24-epibrassinolide (EBR) on the leaf photosynthetic characteristics and polyamines (PAs) content of cucumber seedlings under hypoxia stress. Under the stress, the leaf net photosynthetic rate
Vulnerability of the retinal microvasculature to hypoxia: role of polyamine-regulated K(ATP) channels.
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OBJECTIVE
It is uncertain why retinal capillaries are particularly vulnerable to hypoxia. In this study, it was hypothesized that their specialized physiology, which includes being the predominant microvascular location of functional adenosine triphosphate-sensitive potassium (K(ATP)) channels,
γ-Aminobutyric Acid (GABA) Accumulation in Tea (Camellia sinensis L.) through the GABA Shunt and Polyamine Degradation Pathways under Anoxia.
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γ-Aminobutyric acid (GABA) is an important bioactive component of tea (Camellia sinensis) providing various health benefits. We studied GABA accumulation via the GABA shunt and polyamine degradation pathways under anoxia in tea leaves. Anoxia caused a ∼20-fold increment in GABA concentration,
Multiple polyamine transport pathways in cultured pulmonary artery smooth muscle cells: regulation by hypoxia.
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The polyamines putrescine (PUT), spermidine (SPD), and spermine (SPM) are a family of low molecular weight organic cations that play essential intracellular regulatory roles in cell growth and differentiation. Consistent with this important function, increases in cellular polyamine contents are
[Effects of exogenous gamma-aminobutyric acid on polyamine metabolism of melon seedlings under hypoxia stress].
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Taking melon cultivar 'Xiyu No. 1 ' as test material, a hydroponic experiment was conducted to investigate the effects of exogenous gamma-aminobutyric acid (GABA) on the seedlings polyamine metabolism under hypoxia stress. Compared with the control in normoxic treatment, the seedlings under hypoxia
[Effects of D-arginine on polyamine content and anaerobic respiration metabolism of cucumber seedling roots under hypoxia stress].
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By the method of solution culture, this paper studied the effects of D-arginine on the seedling roots polyamine content and anaerobic respiration metabolism of two cucumber ( Cucumis Sativus L. ) cultivars Zhongnong No. 8 and Lübachun No. 4 differed in hypoxia tolerance. The results showed that
Polyamine biosynthesis and degradation are modulated by exogenous gamma-aminobutyric acid in root-zone hypoxia-stressed melon roots.
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We detected physiological change and gene expression related to PA metabolism in melon roots under controlled and hypoxic conditions with or without 5 mM GABA. Roots with hypoxia treatment showed a significant increase in glutamate decarboxylase (GAD) activity and endogenous GABA concentration.
[Effects of exogenous polyamines on the growth and activities of H+-ATPase and H+-PPase in cucumber seedling roots under hypoxia stress].
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The effects of exogenous polyamines on the growth, polyamines contents, the activities of H(+)-ATPase and H(+)-PPase of plasma membrane and tonoplast in cucumber seedling roots under root-zone hypoxia stress were studied under hydroponic culture. The results showed that the growth of cucumber roots
GABA shunt and polyamine degradation pathway on γ-aminobutyric acid accumulation in germinating fava bean (Vicia faba L.) under hypoxia.
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GABA shunt and polyamine degradation pathway on γ-aminobutyric acid (GABA) accumulation in germinating fava bean under hypoxia was investigated. GABA content, GAD and DAO activity were significantly increased under hypoxia treatment. Glu and polyamine contents enhanced largely and thus supplied as
Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase.
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Hypoxia is a hallmark of solid tumors, which may offer opportunities for targeted therapies of cancer; however, the mechanisms that link hypoxia to malignant transformation and tumor progression are not fully understood. Here, we show that up-regulation of the polyamine system promotes cancer cell
Cultured rat main pulmonary artery smooth muscle cells exhibit at least two polyamine transport phenotypes that differ morphologically and in response to hypoxia.
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[Polyamines and RNA in myocardial hypoxia and anoxia (author's transl)].
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