Kidney Stones

silodosin

Extra-corporeal shock wave lithotripsy

Tamsulosin

Albert Einstein Healthcare Network

Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave Lithotripsy

Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After ESWL

The primary endpoint of this study is the clearance rate of kidney stones. That is, in what period of time does the patient achieve clearance, is stone free and has all residual stones gone. This outcome measure will be measured in days.

Analgesic use, number of pills of pain medication

Residual stones remaining, based on imaging

need for re-treatment. Either the patient will need another ESWL, or hospitilization

need for intervention. Either ESWL again or hospitilization and further procedures such as laser lithotripsy, percutaneous nephrolithotomy, open surgery

steinstrasse clearance. Whether or not stone clearance is achieved or not

need for hospitalization. either yes or no

Richard Harkaway

PRINCIPAL INVESTIGATOR

Intensive care support and Equine F(ab')2 antivenom

Poisoning by Scorpion Sting

A single dose of 4 vials of Equine F(ab')2 antivenom will be administered intravenously over 10 minute

Equine F(ab')2 antivenom

Intensive care support as needed plus placebo

Intensive care support plus placebo

CHU Hassan II de Fès

Hôpital Ibn Zohr, Marrakech

A Trial of Equine F (ab')2 Antivenom for Treatment of Scorpion Envenomation in Morocco

Phase 2/3 Study for Scorpion North Africa Middle East Envenomation With a Immune F(ab')2 (Equine) Antivenom Alacramyn NAMO. A Randomized, Double-Blind, Placebo-controlled, Prospective and Multicenter Study

Comparison between antivenom and placebo groups of the number of cases showing improvement in class of envenomation.

Decrease in plasma venom levels from baseline to one hour after study drug administration; Respiratory rate (breaths per minute); Heart rate (beats per minute); Dose of dobutamine (cumulative, per hour);Incidence of cardiac failure; Incidence of ventilatory failure; Incidence of neurological failure; Mortality

priapism/diarrea

Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave Lithotripsy

A Trial of Equine F (ab')2 Antivenom for Treatment of Scorpion Envenomation in Morocco

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