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Pàgina 1 des de 39 resultats
Anoxia and corporal smooth muscle dysfunction: a model for ischemic priapism.
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The hemodynamics of penile flaccidity, erection and detumescence requires corporal smooth muscle to function across a wide variation in pO2. The present study describes the effect of anoxia on corporal smooth muscle response to field stimulation and pharmacologic agonists and antagonists of
Priapism is associated with sleep hypoxemia in sickle cell disease.
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OBJECTIVE
We assessed penile rigidity during sleep and the relationship of sleep abnormalities with priapism in adults with sickle cell disease.
METHODS
This was a case-control study of 18 patients with sickle cell disease and a history of priapism during the previous year, and 16 controls with
[Medical treatment of venous priapism apropos of 46 cases: puncture, pharmacologic detumescence or penile cooling?].
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OBJECTIVE
To analyse the efficacy of three nonspecific medical approaches to the first-line treatment of priapism : a) intracavernous injection (ICI) of alpha-adrenergic agonists, b) cavernous puncture, c) penile cutaneous cooling.
METHODS
46 cases of venous priapism, due to various aetiologies,
In vitro and in vivo animal models in priapism research.
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BACKGROUND
Priapism is an enigmatic yet devastating clinical phenomenon. In the last two decades, the use of various animal models to study this disorder has dramatically advanced our understanding of this mysterious disorder.
OBJECTIVE
This report reviews various animal models used to study
A pathophysiology-based approach to the management of early priapism.
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Priapism is a rare condition that involves persistent penile erection for greater than 4 h. Distinct variants exist, each with unique characteristics. Ischemic priapism is a painful medical emergency that may occur as a result of veno-occlusion leading to hypoxia and tissue death. Recurrent bouts of
Priapism in sickle cell disease: the case for early implantation of the penile prosthesis.
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OBJECTIVE
Recurrent ischemic priapism in sickle cell (SS) patients often leads to impotence. Blockage of venous outflow by sickle cells leads to anoxia of the cavernosal smooth muscle with subsequent replacement of the erectile tissue with dense fibrosis. This study evaluates the efficacy of early
Priapism: a medical emergency.
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Priapism is defined as a prolonged penile erection that fails to subside despite orgasm. It is a medical emergency which should be diagnosed and treated early to preserve erectile function and avoid corporal fibrosis resulting from anoxia of the corporal tissue. Decompression is usually successful
[Intermittent priapism as a clinical feature of lumbar spinal stenosis].
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BACKGROUND
Lumbar spinal stenosis is defined as a narrowing of the neural canal and foramina that result in compression of the lumbosacral nerve roots or cauda equina. Patients with lumbar spinal stenosis may present a variety of signs and symptoms. One such syndrome is neurogenic intermittent
[Ischemic Priapism Associated with Essential Thrombocythemia : A Case Report].
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A 71-year-old man visited a local urologist with the complaint of continuous painful erection for three days. Penile cavernosal blood data showed acidosis and hypoxia. Thus he was diagnosed with ischemic priapism. After penile aspiration and injection of phenylephrine, erection was temporary
Investigation of cavernosal smooth muscle dysfunction in low flow priapism using an in vitro model.
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The effects of hypoxia (pO2: 50 mmHg), acidosis (pH: 6.9) or glucopenia (absence of glucose) in vitro on the tone of the rabbit corpus cavernosum were investigated. The recovery of smooth muscle contractility following exposure to these conditions was also assessed. Hypoxia, acidosis or glucopenia
Priapism in preterm infant.
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This report of transient priapism in a preterm newborn with respiratory distress syndrome discusses clinical course, therapy, possible etiologic factors, and previously reported cases in newborns. Possible causes include use of arterial catheter, red cell transfusion, hemodynamic changes from a
The occurrence of priapism as a result of the use of a single dose of quetiapine.
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Priapism is a prolonged pathologic erection situation that occurs after sexual stimulation or without sexual stimulation. This condition is divided into two types, ischemic (low-flow, veno-occlusive) and non-ischemic (high-flow, arterial). A 68-year-old male patient applied to our clinic with the
Expression and activity of heme oxygenase-1 in artificially induced low-flow priapism in rat penile tissues.
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BACKGROUND
The inducible isoform of heme oxygenase (HO)-1 regulates the vascular smooth muscle tone and responds to hypoxia.
OBJECTIVE
To investigate the role of HO-1 in a low-flow priapism.
METHODS
Sixty male Sprague-Dawley rats were divided into five groups of six rats each. Each group of rats was
Ischemic priapism as a model of exhausted metabolism.
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In vivo metabolic studies typically concern complex open systems. However, a closed system allows better assessment of the metabolic limits. Ischemic priapism (IP) constitutes a special model of the compartment syndrome that allows direct sampling from a relatively large blood compartment formed by
Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism.
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OBJECTIVE
We identify whether tachyphylaxis and priapism effects of sildenafil are related to regulation of phosphodiesterase-5 (PDE-5) expression.
METHODS
Cavernous smooth muscle cells (CSMCs) were isolated from young rats and treated with 0, 1, 10 and 25 microM sildenafil with or without 100
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