Subjects will have an fMRI the morning of their WBH session and and fill out study questionnaires. Following the fMRI session, the participant will undergo the WBH intervention where subjects will be induced to levels of heat that increases core body temperature to approximately 37.5-38.5 °C.temperature.

Subjects will have an fMRI the morning of their WBH session and and fill out study questionnaires. Following the fMRI session, the participant will undergo the WBH-control intervention where subjects will be induced to levels of heat that causes only a minor increase in body temperature.

Major Depression

The Whole Body Hyperthermia system uses water-filtered infrared-A (wIRA) heat radiation. The rise in the body's core temperature is correspondingly rapid and well-tolerated. There are two phases of the thermal challenge, 1) Irradiation phase during which the patient lies recumbent with his/her head positioned outside the tent. The wIRA irradiators are arranged above the exposed upper part of the body; and 2) Heat retention phase during which the patient lies in the chamber with the walls of the tent positioned to retain heat. Core body temperatures will be raised to those comparable to a mild fever 37.8-38.5°C.

High intensity whole-body infrared heating

Attenuated heating using only heating coils at the bottom of the Heckel device. This results in only a minor increase in skin temperature and no increase in core body temperature. The participant will still feel heat and will see similar lighting and hear similar sounds as those occurring during actual WBH, and will be in the chamber for the same period of time.

Low intensity whole-body infrared heating

A standard magnetic resonance imaging (fMRI) machine will be used to take images of the brain. An standard EKG (compatible with the fMRI machine) will be used to take measurements of cardiac vagal control.

Functional Magnetic Resonance Imaging (fMRI) and electrocardiogram (EKG)

Weekly questionnaires to assess changes in depression, mood, perceptions of self and quality of life will be administered.

Questionnaires

University of Arizona

The Brain on Whole Body Hyperthermia: A Neuroimaging Study

Functional magnetic resonance imaging (fMRI) analyses of resting state brain connectivity.

Functional magnetic resonance imaging (fMRI) analyses of concordance between subgenual anterior cingulate cortex and autonomic nervous system function assessed by electrocardiogram (EKG). The investigators are specifically looking at the inter-relationship between cardiac vagal control and brain activity.

Percent change in scores between baseline and subsequent assessments will be assessed using the Beck Depression Inventory (BDI).

Percent change in positive and negative affect will be assessed between baseline and subsequent assessments using the Positive and Negative Affect Schedule (PANAS)

Percent change in scores between baseline and subsequent assessments will be assessed the Sheehan Disability Scale (SDS).

Percent change in scores between baseline and subsequent assessments will be assessed using the Quality of Life and Enjoyment Scale (Q-LES).

Charles (Chuck) Raison

Associate Professor, Department of Psychiatry (College of Medicine) and the Norton School of Family and Consumer Sciences

Anaesthesia

receive intravenous injection of 0.2 mL/kg of saline 0.9%L [group P]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

Placebo [group P]

receive intravenous injection of 0.2 mL/kg of aminophylline 10 mg/mL [group A2]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

0.2 mL/kg of aminophylline 10 mg/mL [group A2]

receive intravenous injection of 0.2 mL/kg of aminophylline 15 mg/mL [group A3]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

0.2 mL/kg of aminophylline 15 mg/mL [group A3]

receive intravenous injection of 0.2 mL/kg of aminophylline 20 mg/mL [group A4]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

0.2 mL/kg of aminophylline 20 mg/mL [group A4]

receive intravenous injection of 0.2 mL/kg of aminophylline 25 mg/mL [group A5]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

0.2 mL/kg of aminophylline 25 mg/mL [group A5]

receive intravenous injection of 0.2 mL/kg of doxapram 5 mg/mL [group D]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

Doxapram 1 mg/kg [group D]

King Faisal University

Aminophylline and Cognitive Function After Sevoflurane Anaesthesia

Aminophylline Improves Early Postoperative Cognitive Recovery After Sevoflurane Anaesthesia: A Dose-Dependent Study

The SOMCT is a patient-based test designed to assess cognitive function in terms of level of orientation, memory, and concentration.

substance dependence/febre

The Brain on Whole Body Hyperthermia: A Neuroimaging Study

Aminophylline and Cognitive Function After Sevoflurane Anaesthesia

La base de dades d’herbes medicinals més completa avalada per la ciència