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10'-fluorinated Vinca alkaloids provide enhanced biological activity against MDR cancer cells
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BACKGROUND ART
Vinca alkaloids, originally isolated from the periwinkle plant [Vinca rosea Linn., now Cantharanthus roseus (L.) G. Don] are a family of indole-indoline dimeric compounds that contain a four-ring system containing an indole linked to a five-ring system containing an indoline. Two of
Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties
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FIELD OF THE INVENTION
This invention relates to the fields of biochemistry and medicine, and particularly to a pharmaceutical preparation which includes liposome-entrapped water soluble drug formulations, and methods of using such formulations to control the delivery of encapsulated agents to
Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties
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FIELD OF THE INVENTION
This invention relates to the fields of biochemistry and medicine, and particularly to a pharmaceutical preparation which includes liposome-entrapped water soluble drug formulations, and methods of using such formulations to control the delivery of encapsulated agents to
Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties
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FIELD OF THE INVENTION
This invention relates to the fields of biochemistry and medicine, and particularly to a pharmaceutical preparation which includes liposome-entrapped water soluble drug formulations, and methods of using such formulations to control the delivery of encapsulated agents to
Method for treating cancers using a diiodo thyronine analogue having no significant hormonal activity and a vinca alkaloid and compositions comprising the same
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The present invention is in the field of biochemistry and pharmacology. Specifically, the present invention relates to methods for treating cancers and malignancies by administering a pharmaceutically effective amount of a diiodo thyronine analogue having no significant hormonal activity and a vinca
Liposome-encapsulated vinca alkaloids and their use in combatting tumors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to the use of vinca alkaloids in combatting tumors.
2. Discussion of the Background
The dimeric alkaloids, vincristine and vinblastine, containing indol-indoline moieties from Catharanthus species are widely used as
Vinca alkaloid intermediates
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BACKGROUND OF THE INVENTION
Several naturally-occurring alkaloids obtainable from Vinca rosea have been found active in the treatment of experimental malignancies in animals. Among these are leurosine (U.S. Pat. No. 3,370,057), vincaleukoblastine (vinblastine) to be referred to hereinafter as VLB
Oxazolidinedione derivatives of Vinca alkaloids
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BACKGROUND OF THE INVENTION
Several naturally-occurring alkaloids obtainable from Vinca rosea have been found active in the treatment of experimental malignancies in animals. Among these are leurosine (U.S. Pat. No. 3,370,057), vincaleukoblastine (vinblastine) to be referred to hereinafter as VLB
Preparation of oxazolidinedione derivatives of Vinca alkaloids
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BACKGROUND OF THE INVENTION
Several naturally-occurring alkaloids obtainable from Vinca rosea have been found active in the treatment of experimental malignancies in animals. Among these are leurosine (U.S. Pat. No. 3,370,057), vincaleukoblastine (vinblastine) to be referred to hereinafter as VLB
Use of vinca alkaloids and salts thereof
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TECHNICAL FIELD
The present invention relates to the use of vinca alkaloids and their salts. More specifically, the present invention relates to agents that enhance insulin-producing and/or -secreting abilities of non-neoplastic cells derived from the pancreas, therapeutic agents for diabetes, blood
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