PEF-Block & Ribs Fractures
Klíčová slova
Abstraktní
Termíny
Poslední ověření: | 12/31/2017 |
První předloženo: | 12/14/2017 |
Odhadovaná registrace vložena: | 01/03/2018 |
První zveřejnění: | 01/10/2018 |
Poslední aktualizace byla odeslána: | 06/25/2018 |
Poslední aktualizace zveřejněna: | 06/27/2018 |
Aktuální datum zahájení studie: | 06/17/2018 |
Odhadované datum dokončení primární: | 06/17/2018 |
Odhadované datum dokončení studie: | 12/19/2020 |
Stav nebo nemoc
Intervence / léčba
Procedure: Control Arm
Procedure: Posterior exo-thoracic fascia block arm
Procedure: Paravertebral block arm
Fáze
Skupiny zbraní
Paže | Intervence / léčba |
---|---|
Active Comparator: Control Arm Pain management use intravenous morphine patient-controlled analgesia (PCA) | Procedure: Control Arm Group 1 control:
Morphine titration at 0.1 mg/kg
Establishment of PCA morphine:
concentration 1mg/ml
1ml bolus
refractory period of 7 minutes
no maximum dose per day. Premedication of the patient with Ketamine 0.15 mg/kg and Propofol 0.5 mg /kg |
Experimental: Posterior exo-thoracic fascia block arm Pain management use intravenous morphine patient-controlled analgesia (PCA) and a block of the posterior exo-thoracic fascia with Ropivacaine | Procedure: Posterior exo-thoracic fascia block arm Group 2 PEF block:
Establishment of PCA morphine:
concentration 1mg / ml
1ml bolus
refractory period of 7 minutes
no maximum dose per day.
Realization of a block of the posterior exo-thoracic fascia (PEF block) at the median level of ribs fractures with ropivacaine 5mg / mL, 3 mg / kg under echography guidance. ALR needle (type neurostimulation) with a length of 100 mm is used. When the injection is performed an analgesia catheter is deposited in the space created by local anesthetics. Realization of ropivacaine bolus 2mg / ml at 0.1ml/kg every 4 hours. Possibility of an additional bolus of 0.1ml / kg every hour if insufficient analgesia. |
Experimental: Paravertebral block arm Pain management use intravenous morphine patient-controlled analgesia (PCA) and a block of paravertebral space with Ropivacaine | Procedure: Paravertebral block arm Group 3 paravertebral block:
Establishment of PCA morphine:
concentration 1mg / ml
1ml bolus
refractory period of 7 minutes
no maximum dose per day.
Realization of a paravertebral block (BPV) at the median level of ribs fractures ropivacaine 5mg / mL, (0.3ml / kg) 1.5 mg / kg under echography guidance. ALR needle (type neurostimulation) with a length of 100 mm is used. When the injection is performed an analgesia catheter is deposited in the space created by local anesthetics. Realization of bolus of ropivacaine 2mg / ml at 0.1ml / kg every 4 hours.
Possibility of an additional bolus of 0.1ml / kg every hour if insufficient analgesia.
In the case of failure of initial management with significant pain despite the iterative boli, epidural analgesia is used in recourse. |
Kritéria způsobilosti
Věky způsobilé ke studiu | 18 Years Na 18 Years |
Pohlaví způsobilá ke studiu | All |
Přijímá zdravé dobrovolníky | Ano |
Kritéria | Inclusion Criteria: - Major patients (18-80 years old) - Affiliated to the social security - Hospitalized following severe trauma associated with at least 2 unilateral ribs fractures - EVA greater than or equal to 3 when coughing or when mobilizing care. - Management of the patient in the first 24 hours post trauma. - Patient not intubated. - Collection of informed written consent, notification on the anesthesia sheet. Exclusion Criteria: - Minor patients, - Patients under guardianship - Pregnant or lactating women - Allergy known to local anesthetics, - Severe coagulopathy, - Infection of the puncture site - Neuromuscular pathology - Chronic pain patients (long-term treatment with non-inflammatory steroidal, opioid, neuroleptic, antidepressant, antiepileptic), - Intubated patient |
Výsledek
Primární výsledná opatření
1. Consumption of opoïd [24 hours]
Měření sekundárních výsledků
1. cough pain intensity [1 hour, 6hours, 12hours, 24hours]