Fatty Acid Biomarkers of Carbohydrate Intake
Klíčová slova
Abstraktní
Popis
In this isocaloric clinical cross-over trial, the investigators aim to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality. The investigators intend to evaluate if changes in carbohydrate quantity and quality (including sugar) influence circulating even-chain saturated fatty acids or if fatty acid-derived indices of desaturation and de novo lipogenesis are more sensitive biomarkers of carbohydrate intake. By performing untargeted lipidomic analyses, the investigators aim to search for novel lipid biomarkers of carbohydrate quantity and quality. The investigators also want to evaluate the influence of moderate alterations of carbohydrate and sugar intake on lipoproteins, insulin sensitivity, inflammatory proteins.
Termíny
| Poslední ověření: | 10/31/2018 |
| První předloženo: | 09/21/2017 |
| Odhadovaná registrace vložena: | 09/21/2017 |
| První zveřejnění: | 09/26/2017 |
| Poslední aktualizace byla odeslána: | 11/13/2018 |
| Poslední aktualizace zveřejněna: | 11/14/2018 |
| Aktuální datum zahájení studie: | 10/24/2017 |
| Odhadované datum dokončení primární: | 05/31/2018 |
| Odhadované datum dokončení studie: | 05/31/2018 |
Stav nebo nemoc
Intervence / léčba
Other: Low carbohydrate diet
Other: High carbohydrate, high sugar diet
Other: High carbohydrate, low sugar diet
Fáze
Skupiny zbraní
| Paže | Intervence / léčba |
|---|---|
| Active Comparator: Fat - Sugar - Fiber Intervention: consuming diets rich in fat, rich in sugar, and rich in fibers during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. | |
| Active Comparator: Fat - Fiber - Sugar Intervention: consuming diets rich in fat, rich in fiber, and rich sugar during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. | |
| Active Comparator: Sugar - Fiber - Fat Intervention: Consuming diets rich in sugar, rich in fiber, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. | |
| Active Comparator: Sugar - Fat - Fiber Intervention: Consuming diets rich in sugar, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. | |
| Active Comparator: Fiber - Sugar - Fat Intervention: Consuming diets rich in fiber, rich in sugar, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. | |
| Active Comparator: Fiber - Fat - Sugar Intervention: consuming diets rich in fiber, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet. |
Kritéria způsobilosti
| Věky způsobilé ke studiu | 20 Years Na 20 Years |
| Pohlaví způsobilá ke studiu | All |
| Přijímá zdravé dobrovolníky | Ano |
| Kritéria | Inclusion Criteria: - BMI 20-38 Exclusion Criteria: - abnormal lab tests (assessed by screening and judged by a physician), diabetes, cardiovascular, kidney, liver or malignant disease, and weight-loss (±3kg) the preceding 3 months of screening. Extreme diets, i.e. very-low carbohydrate diets, intermittent fasting, vegan diets or allergic to gluten |
Výsledek
Primární výsledná opatření
1. Palmitic acid in different plasma fractions [14-20 days]
Měření sekundárních výsledků
1. Even-chain saturated fatty acids (i.e. 14:0, 18:0) and monounsaturated fatty acids [14-20 days]
Další výsledková opatření
1. Desaturation indices end lipogenic indices [14-20 days]
