Strontium Ranelate and KOA
Klíčová slova
Abstraktní
Popis
The present study was carried out on thirty patients with primary knee osteoarthritis. Patients were recruited from Rheumatology and Rehabilitation
Outpatient Clinic at Mansoura University Hospi Patients were divided into two groups:
Group 1: included 15 patients who received oral strontium ranelate and physiotherapy program. The age of the patients ranged from 50 to 62 years, they were 11 females and 4 males. Group 2: included 15 patients who received physiotherapy program. The age of the patients ranged from 50 to 62 years, they were 12 females and 3 males. Written consent was obtained from each participant sharing in the study. This study was approved by the institution research board of faculty of medicine, Mansoura University, code: MS/15.10.08.
InclusionAll patients were subjected to the following:
I. History Taking :
1. Personal History
- Name, age, sex, residence, marital status.
- Occupational status.
- Special habits e.g. smoking status (current/previous).
2. Complaint:
Taken in the patient's own words with special stress on disease duration.
3. Present history:
Onset, course and duration of disease. Analysis of complaint Pain: type of pain, site of pain, factors participating/alleviating pain. Swelling. Crepitus. Limitation of movement. Morning and inactivity stiffness, its duration and location. Other joints affected and its pattern of distribution.
History of other systems affections:
Neurological symptoms (muscle power and sensation of the lower limbs). Eye symptoms (redness, ulcers and blurred vision). Gastrointestinal tract (GIT) symptoms (diarrhea, heart burn and mucus in the stool). Urinary tract (UT) symptoms (dysuria and frequency). Skin affection (ulcers, erythema, papules and nodules).
4. Past history:
History of surgical operation of knee.
HistoryAssessment of range of motion of the affected knee joint:
For any limitation in the range of motion of the knee joint.
D) Special tests to assess ligaments and menisci:
Varus stress test for lateral collateral ligament. Valgus stress test for medial collateral ligament. Anterior drawer test for anterior cruciate ligament. Posterior drawer test for posterior cruciate ligament.
McMurry's test for menisci.Radiological investigations:
Termíny
| Poslední ověření: | 04/30/2018 |
| První předloženo: | 05/01/2019 |
| Odhadovaná registrace vložena: | 05/01/2019 |
| První zveřejnění: | 05/02/2019 |
| Poslední aktualizace byla odeslána: | 05/02/2020 |
| Poslední aktualizace zveřejněna: | 05/04/2020 |
| Aktuální datum zahájení studie: | 06/30/2018 |
| Odhadované datum dokončení primární: | 06/30/2019 |
| Odhadované datum dokončení studie: | 12/31/2019 |
Stav nebo nemoc
Intervence / léčba
Drug: strontium ranelate
Other: physiotherapy
Fáze
Skupiny zbraní
| Paže | Intervence / léčba |
|---|---|
| Other: strontium ranelate included 15 patients who received oral strontium ranelate and physiotherapy program. The age of the patients ranged from 50 to 62 years, | Drug: strontium ranelate Patients received strontium ranelate 2gm (one sachet daily with 50 ml water at bedtime at least 2 h after food), as the compliance of patient assessed by counting number of sachet that patient returns at every visit and safety is assessed by recording adverse effects as blood pressure and heart rate every visit and patients received physiotherapy program in the form of (US therapeutic acoustic radiation and exercise program) 3 times per week for 6 months.
Ultra sound (US):
Pulsed ultrasonic waves were delivered at a 1 MHz frequency and at an intensity of 1 watt/ cm2 via a transducer with a diameter of 5 cm and effective radiating area of 3.5 to 5cm² for 9.5 min ( |
| Other: physiotherapy included 15 patients who received physiotherapy program. The age of the patients ranged from 50 to 62 years |
Kritéria způsobilosti
| Věky způsobilé ke studiu | 50 Years Na 50 Years |
| Pohlaví způsobilá ke studiu | All |
| Přijímá zdravé dobrovolníky | Ano |
| Kritéria | Inclusion Criteria: Patients aged ≥ 40 years with symptoms of knee osteoarthritis Exclusion Criteria: rheumatoid arthritis, spondyloarthropathy |
Výsledek
Primární výsledná opatření
1. change of pain from base line [immediately before intervention,3 monthes after intervention,6 monthes after intervention]
Měření sekundárních výsledků
1. change of function from base line [immediately before intervention,3 monthes after intervention,6 monthes after intervention]
2. change of MRI findings from base line [immediately before intervention and 6 monthes after intervention]
